203811

Bryostatin 1

≥98% (HPLC), solid,film, antitumor agent, Calbiochem^®

• Sinónimos: Bryostatin 1, Bryo 1, PKC Activator VII, PKC Activator VI
• Fórmula empírica (notación de Hill): C₄₇H₆₈O₁₇
• Número de CAS: 83314-01-6
• Peso molecular: 905.03
• Número MDL: MFCD00893832
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nombre del producto: Bryostatin 1, A macrocyclic lactone with antitumor properties.
• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: film; solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white to colorless
• solubilidad: DMSO: 25 mg/mL; ethanol: 25 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• InChI: 1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35?,36?,37?,38?,43+,46+,47-/m1/s1
• Clave InChI: MJQUEDHRCUIRLF-BXOMOELISA-N

Descripción

Descripción general

A macrocyclic lactone that exhibits anti-tumor properties. Potently activates protein kinase C and exhibits high binding affinity (K_i = 1.35 nM). Effectively translocates protein kinase C (PKC) isozymes α, β, and ε and induces a biphasic, concentration-dependent, down-regulation of PKC δ. Reported to compete with phorbol esters in binding to PKC. Stimulates protein kinase D (PKD) activity in a biphasic, PKC-dependent manner in intact cells. Also activates Ras in Jurkat T cells and in rat2 cells.

A macrocyclic lactone with antitumor properties. Potently activates protein kinase C and exhibits a high binding affinity (K_i = 1.35 nM). Effectively translocates and down-regulates PKC isozymes α, δ, and ε. Induces a biphasic activation of PKD through a PKC-dependent pathway in intact cells. Also shown to activate Ras in Jurkat T cells and in rat2 cells.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
Protein kinase C

Product does not compete with ATP.

Reversible: no

Target K_i: 1.35 nM for protein kinase C

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Clamp, A., and Jayson, G. 2002. Anticancer Drugs13, 673.
Lorenzo, P.S., et al. 1999. Cancer Res.59, 6137.
Wang, Q.J., et al. 1999. J. Biol. Chem.274, 37233.
Wender, P.A., et al. 1998. Proc. Natl. Acad. Sci. USA95, 6624.
Matthews, S.A., et al. 1997. J. Biol. Chem.272, 20245.
Szallasi, Z., et al. 1994. Mol. Pharmacol.46, 840.
Berkow, R.L., and Kratt, A.S. 1985. Biochem. Biophys. Res. Commun.3, 1109.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable