178501
Palmostatin B
≥95% (HPLC), solid, APT1 inhibitor, Calbiochem®
Sinónimos:
APT1 Inhibitor, palmostatin B, APT1 Inhibitor
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About This Item
Fórmula empírica (notación de Hill):
C23H36O4
Peso molecular:
376.53
Código UNSPSC:
12352200
NACRES:
NA.77
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Nombre del producto
APT1 Inhibitor, palmostatin B, The APT1 Inhibitor, palmostatin B controls the biological activity of APT1.
Nivel de calidad
Ensayo
≥95% (HPLC)
Formulario
solid
fabricante / nombre comercial
Calbiochem®
condiciones de almacenamiento
OK to freeze
protect from light
color
off-white
solubilidad
DMSO: 100 mg/mL
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Descripción general
A cell-permeable, beta-lactone acyl protein thioesterase 1 (APT1) inhibitor (IC50 = 0.67 µM, in an enzymatic assay) that is shown to specifically block Ras depalmitoylation, without affecting Ras acylation, in MDCK cells, both in vitro and in vivo. It induces a marked redistribution of NRas to endomembranes (1 µM) without notable cytotoxicity, and is shown to elicit a loss of the precise steady-state localization of palmitoylated Ras proteins in the same cell line. At 50 µM, this inhibitor displays a partial phenotypic reversion in oncogenic HRasG12V-transformed fibroblasts. Furthermore, it demonstrates selectivity for APT1 over phospholipase A1, A2, Cβ and D. It′s inhibitory effect is demonstrated to be consistent with that of APT1 downregulation by siRNA. Also available as a 50 mM solution in DMSO (Cat. No. 508738).
Envase
Packaged under inert gas
Advertencia
Toxicity: Standard Handling (A)
Otras notas
Dekker, F. and Hedberg, C. 2011. Bioorg. Med. Chem. Lett.19, 1376.
Dekker, F., et al. 2010. Nat. Chem. Biol.6, 449.
Dekker, F., et al. 2010. Nat. Chem. Biol.6, 449.
Información legal
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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