165350

PARP Inhibitor I, 3-ABA

The PARP Inhibitor I, 3-ABA, also referenced under CAS 3544-24-9, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Sinónimos: PARP Inhibitor I, 3-ABA, 3-Aminobenzamide
• Fórmula empírica (notación de Hill): C₇H₈N₂O
• Número de CAS: 3544-24-9
• Peso molecular: 136.15
• Número MDL: MFCD00007989
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥99% (GC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• color: white
• solubilidad: ethanol: 1 mg/mL; water: 1 mg/mL; DMSO: 5 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 10-30°C
• cadena SMILES: Nc1cc(ccc1)C(=O)N
• InChI: 1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)
• Clave InChI: GSCPDZHWVNUUFI-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable anti-proliferative agent that acts as an inhibitor of poly(ADP-ribose) polymerase (PARP). Has minimal effect on bacterial toxin-mediated ADP-ribosylation. An inhibitor of UV-induced apoptosis. Also strongly inhibits K562 target cell killing by human effector natural killer cells.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
PARP

Product does not compete with ATP.

Reversible: no

Advertencia

Toxicity: Irritant (B)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C ). Stock solutions are stable for 3 months at -20°C.

Otras notas

Tiozzo, R., et al. 1996. Biochem. Biophys. Res. Commun. 225, 826.
Malorni, W., et al. 1995. Biochem. Biophys. Res. Commun. 207, 715.
Malorni, W., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1250.
Monti, D., et al. 1994. Biochem. Biophys. Res. Commun.199, 525.
Kozak, K.R., and Ross, I.A. 1991. Biochem. Biophys. Res. Commun.179, 1225.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3