149101-M

1-Aminocyclopropanecarboxylic acid

≥98% (TLC), crystalline solid, NMDA agonist, Calbiochem

• Sinónimos: 1-Aminocyclopropane-1-carboxylic Acid, ACPC
• Fórmula empírica (notación de Hill): C₄H₇NO₂
• Número de CAS: 22059-21-8
• Peso molecular: 101.10
• Número MDL: MFCD00009944
• Código UNSPSC: 12352106
• NACRES: NA.77

Propiedades

• product name: 1-Aminocyclopropane-1-carboxylic Acid, An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex.
• Nivel de calidad: 100
• Análisis: ≥98% (TLC)
• formulario: crystalline solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• solubilidad: water: 40 mg/mL
• temp. de almacenamiento: 10-30°C
• InChI: 1S/C4H7NO2/c5-4(1-2-4)3(6)7/h1-2,5H2,(H,6,7)
• Clave InChI: PAJPWUMXBYXFCZ-UHFFFAOYSA-N

Descripción

Descripción general

A potent and selective ligand for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Blocks ³H-glycine binding to rat forebrain membranes (IC₅₀ = 38 nM).

An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Mimics the effects of glycine on the NMDA receptor ion channel and blocks ³H-glycine binding to rat forebrain membrane (IC₅₀ = 38 nM). Blocks NMDA-induced release of arachidonic acid (IC₅₀ = 131 µM) in cerebellar granule cells. Reduces NMDA-induced cell death in hippocampal neurons.

Acciones bioquímicas o fisiológicas

Primary Target
Glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex

Target IC₅₀: 38 nM in blocking 3H-glycine binding to rat forebrain membrane; 131 µM in blocking NMDA-induced release of arachidonic acid; 131 µM in cerebellar granule cells

Advertencia

Toxicity: Irritant (B)

Nota de preparación

May require heating and sonication to achieve complete solubilization.

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Otras notas

Viu, E., et al. 1998. J. Pharm. Exp. Ther.285, 527.
Zapata, A., et al. 1996. NeuroReport7, 397.
Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
Rottmann, W.H., et al. 1991. J. Mol. Biol.222, 937.
Marvizon, J.C., et al. 1989. J. Neurochem.52, 992.
Nadler, V., et al. 1988. Eur. J. Pharmacol.157, 115.
Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA76, 170.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable