14-813
UbcH7 Conjugating Enzyme, 100 µg
UbcH7 is a class I enzyme which functions in the stress response & the control of transcription factors. The enzyme is ubiquitously expressed with high levels of expression seen in adult muscle.
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About This Item
Código UNSPSC:
12352204
eCl@ss:
32160405
NACRES:
NA.32
Productos recomendados
origen biológico
human
Nivel de calidad
Análisis
>95% (SDS-PAGE)
mol peso
Mw 18 kDa
fabricante / nombre comercial
Upstate®
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
dry ice
Información sobre el gen
human ... UBE2G2(7327)
Descripción general
Product Source: Recombinant human UbcH7 Conjugating Enzyme expressed in E. coli.
UbcH7 is a class I enzyme which functions in the stress response and the control of transcription factors. The enzyme is ubiquitously expressed with high levels of expression seen in adult muscle. It has been demonstrated to participate in the ubiquitinylation of p53, c-Fos and NF-κB. UbcH7 is one of two E2s (UbcH5 being the other) with which HECT domain proteins interact with UbcH7 being able to efficiently substitute for UbcH5 in E6-AP-dependent ubiquitinylation. Typical enzyme concentration to support conjugation in vitro is 100nM to 1μM depending upon conditions.
Forma física
Purified using Ni2+ chelation chromatography with Ni2+ in limiting concentration.
Almacenamiento y estabilidad
Stable for 1 year at -80°C from date of shipment. Avoid multiple freeze/thaw cycles. After initial defrost, aliquot into individual tubes and refreeze at -80°C.
Información legal
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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K K Chung et al.
Nature medicine, 7(10), 1144-1150 (2001-10-09)
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U Nuber et al.
The Journal of biological chemistry, 271(5), 2795-2800 (1996-02-02)
E6-AP, a 100-kDa cellular protein, was originally identified through its interaction with the E6 protein of the oncogenic human papillomavirus types 16 and 18. The complex of E6-AP and E6 specifically interacts with p53 and mediates ubiquitination of p53 in
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