14-404-M

ZAP-70 Protein, active, 20 µg

Active, recombinant, human, full length ZAP-70 containing a C-terminal His6 tag, for use in Kinase Assays.

• Sinónimos: 70 kDa zeta-chain associated protein, SRK, Syk-related tyrosine kinase
• Código UNSPSC: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

Propiedades

• origen biológico: human
• Nivel de calidad: 100
• recombinante: expressed in Sf21 cells
• formulario: liquid
• caducidad: 6 mo.
• mol peso: M_w 70 kDa
• fabricante / nombre comercial: Upstate^®
• técnicas: activity assay: suitable (kinase)
• Nº de acceso NCBI: NM_001079.3; NM_207519.1
• Nº de acceso UniProt: P43403
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... ZAP70(7535)

Descripción

Descripción general

Research area: CELL SIGNALING

Product Source: expressed in Sf21 Recombinant, human, full length ZAP-70 containing a C-terminal His6-tag

Zeta-chain-associated protein kinase 70 (ZAP-70) is a cytoplasmic tyrosine kinase that consists of tandem SH2 (tSH2) domains at the beginning, linked with a long linker region, and a tyrosine kinase domain at the C-terminal end.

Acciones bioquímicas o fisiológicas

Protein Target: ZAP-70

Target Sub-Family: TK

Zeta-chain-associated protein kinase 70 (ZAP-70) plays a vital role in the development and function of T cells and natural killer cells. It interacts directly with the activated T-cell receptor and regulates downstream signals. In addition, ZAP-70 also mediates B-cell receptor (BCR) signaling. Mutations in ZAP-70 have been associated with severe combined immunodeficiency (SCID), chronic lymphocytic leukemia (CLL) , and the development of autoreactive T cells that attack the joints.

Calidad

routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1) substrate peptide

Forma física

Ni²⁺/NTA-agarose

Almacenamiento y estabilidad

6 months at -20C

Otras notas

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Información legal

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1