14-326-M
Src Protein, active, 10 µg
Active, N-Terminal His6-tagged, recombinant, full-length, human Src. For use in Kinase Assays.
Sinónimos:
SRC1
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About This Item
Código UNSPSC:
12352202
eCl@ss:
32160405
NACRES:
NA.26
Productos recomendados
origen biológico
human
Nivel de calidad
recombinante
expressed in Sf21 cells
Formulario
liquid
mol peso
Mw 61.7 kDa
fabricante / nombre comercial
Upstate®
técnicas
activity assay: suitable (kinase)
solubilidad
soluble
Nº de acceso NCBI
Nº de acceso UniProt
Información sobre el gen
human ... SRC(6714)
Descripción general
Research area: Cell Signaling
N-Terminal His6-tagged, recombinant, full-length, human Src.
Src proteins are non-receptor protein tyrosine kinases, that belong to the Src family of kinases. These proteins have a unique structure consisting of an N-terminal region with a 14-carbon myristoyl group, two Src homology domains (SH2 and SH3), a catalytic tyrosine-protein kinase domain (SH1), and a short C-terminal tail. The SH1 domain is catalytic in function, while the SH2 and SH3 domains are non-catalytic and regulatory in nature.
Product Source: Human c-src, expressed in Sf21 cells.
N-Terminal His6-tagged, recombinant, full-length, human Src.
Src proteins are non-receptor protein tyrosine kinases, that belong to the Src family of kinases. These proteins have a unique structure consisting of an N-terminal region with a 14-carbon myristoyl group, two Src homology domains (SH2 and SH3), a catalytic tyrosine-protein kinase domain (SH1), and a short C-terminal tail. The SH1 domain is catalytic in function, while the SH2 and SH3 domains are non-catalytic and regulatory in nature.
Product Source: Human c-src, expressed in Sf21 cells.
Aplicación
The Src protein may be used to study the interaction between CD133 and Src protein and its effect on FAK phosphorylation and cell migration through in vitro kinase assay.
Acciones bioquímicas o fisiológicas
Src protein tyrosine kinases are involved in signaling pathways that control a plethora of cellular functions ranging from cell cycle, proliferation, differentiation, gene transcription, immune responses, apoptosis, etc. Upon its activation, Src phosphorylates and activates several other kinases Like MAPK (Mitogen-Activated Protein Kinase), p38, and ERK (Extracellular signal-regulated kinase). Activated MAPK (Mitogen-Activated Protein Kinase) regulates inflammation, cell development, differentiation and senescence. P38 is involved with the migration and survival of endothelial cells and extracellular signal-regulated kinase (ERK) promotes the proliferation and inflammation of endothelial cells. They play a key role in the regulation of cytoskeletal organization through the phosphorylation of substrates like Actin filament-associated protein 1 (AFAP1) and cortactin (CTTN). Src also plays a crucial role in maintaining cell adhesion, morphology, motility, and bone resorption by interacting with focal adhesion kinases. Src tyrosine kinase activity is upregulated in a variety of cancers including colon, lung, and pancreatic cancer, etc.
Envase
2 vials at 5μg each
Also available in 250μg size (2x125μg)--call for pricing and availability and reference catalog number 14-326M when ordering the 250μg size.
Also available in 250μg size (2x125μg)--call for pricing and availability and reference catalog number 14-326M when ordering the 250μg size.
Calidad
Routinely evaluated by phosphorylation of Src Substrate Peptide
Otras notas
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Información legal
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Skin Sens. 1
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Protein tyrosine kinases, with emphasis on the Src family.
Courtneidge, S A
Seminars in Cancer Biology, 5, 239-246 (1994)
Jianhui Ma et al.
Cancer cell, 35(3), 504-518 (2019-03-05)
Ionizing radiation (IR) and chemotherapy are standard-of-care treatments for glioblastoma (GBM) patients and both result in DNA damage, however, the clinical efficacy is limited due to therapeutic resistance. We identified a mechanism of such resistance mediated by phosphorylation of PTEN
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