1.07185

Pepsin

(from porcine gastric mucosa) 0.7 FIP-U/mg for biochemistry EC 3.4.23.1

• Sinónimos: Pepsin
• Número de CAS: 9001-75-6
• Peso molecular: 35000
• Número MDL: MFCD00081840
• Código UNSPSC: 12352204
• Número índice de la CE: 232-629-3
• NACRES: NA.21

Propiedades

• pH: 4.0-5.0 (20 °C, 10 g/L in H₂O)
• solubilidad: 10 g/L
• densidad aparente: 380‑420 kg/m³
• temp. de almacenamiento: 2-30°C

Descripción

Aplicación

Pepsin has been used in the preparation of simulated gastric fluid to perform in vitro gastric digestion.

Acciones bioquímicas o fisiológicas

Pepsin is a component of gastric juice and is associated with protein digestion. It is an endopeptidase that catalyzes the degradation of proteins into peptides and amino acids for small intestinal absorption. Pepsin is released as a zymogen (pepsinogen) by the chief cells of the gastric lining. It gets activated by the acidic environment created by the hydrochloric acid (HCl) of gastric juice. Pepsin is active at pH 1.5 to 2, in the stomach. It is involved in the conversion of food bolus into chyme. It is associated with laryngopharyngeal reflux (LPR) indicated by chronic cough, mild dysphagia, hoarseness, and non-productive throat clearing.

Nota de análisis

Appearance: fine, slightly yellow powder
Activity/FIP (Hemoglobin; pH 1.6; 25 °C): ≥ 0.70 FIP-U/mg
pH-value (1 %; water): 4.0 - 5.0
Water (according to Karl Fischer): ≤ 6.0 %

Información de seguridad

• Pictogramas: GHS07,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H315 - H319 - H334 - H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable