104550

ACA

A cell-permeable inhibitor of phospholipase A2 that blocks epinephrine-stimulated thromboxane production in platelets.

• Sinónimos: ACA, N-( p-Amylcinnamoyl)anthranilic Acid, N-(p-Amylcinnamoyl)anthranilic Acid
• Fórmula empírica (notación de Hill): C₂₁H₂₃NO₃
• Número de CAS: 110683-10-8
• Peso molecular: 337.41
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Análisis: ≥99% (HPLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: ethanol: 10 mg/mL; DMSO: 50 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 10-30°C
• InChI: 1S/C21H23NO3/c1-2-3-4-7-16-10-12-17(13-11-16)14-15-20(23)22-19-9-6-5-8-18(19)21(24)25/h5-6,8-15H,2-4,7H2,1H3,(H,22,23)(H,24,25)/b15-14+
• Clave InChI: GAMRBCZMOOMBSQ-CCEZHUSRSA-N

Descripción

Descripción general

A cell-permeable inhibitor of phospholipase A₂ that blocks epinephrine-stimulated thromboxane production in platelets. Inhibits ATP-stimulated phosphatidylcholine (PC) secretion in alveolar type II cells. Also blocks phorbol ester and A23187-induced PC secretion in type II cells. Reported to block glucose-induced insulin secretion by pancreatic β-cells. Exhibits moderate leukotriene antagonist activity.

Inhibits epinephrine-stimulated thromboxane production (86% at 3.5 μM) via inhibition of phospholipase A₂ (PLA₂) in human platelets. Also blocks glucose-induced insulin secretion in pancreatic islets. Possesses moderate leukotriene antagonist activity.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
A2PLA2

Product does not compete with ATP.

Reversible: no

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Liu, L., et al. 1999. J. Cell. Biochem.72, 103.
Simonsson, E., et al. 1998. Diabetes47, 1436.
Konrad, R.J., et al. 1992. Biochim. Biophys. Acta1135, 215.
Banga, H.S., et al. 1986. Proc. Natl. Acad. Sci. USA83, 9197.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable