1.01005

1,1,1-Trichloro-2-methyl-2-propanol hemihydrate

EMPROVE^® ESSENTIAL, Ph. Eur., BP, JP, NF

• Sinónimos: 1,1,1-Trichloro-2-methyl-2-propanol hemihydrate, Acetone chloroform, Chlorbutol, Chloretone, Chlorobutanol
• Fórmula empírica (notación de Hill): C₄H₇Cl₃O · 0.5H₂O
• Número de CAS: 6001-64-5
• Peso molecular: 186.46
• Número MDL: MFCD02179352
• Código UNSPSC: 12352104
• Número índice de la CE: 200-317-6

Propiedades

• Agency: BP; JP; NF; Ph. Eur.
• Nivel de calidad: 500
• Línea del producto: EMPROVE^® ESSENTIAL
• formulario: solid
• pH: 4.5-6 (20 °C, 7.7 g/L in H₂O)
• bp: 167 °C/1013 hPa
• mp: 78 °C
• temperatura de transición: flash point 100 °C
• solubilidad: 7.7 g/L
• aplicaciones: liquid formulation; ophthalmics; pharmaceutical
• temp. de almacenamiento: 15-25°C
• InChI: 1S/2C4H7Cl3O.H2O/c2*1-3(2,8)4(5,6)7;/h2*8H,1-2H3;1H2
• Clave InChI: WRWLCXJYIMRJIN-UHFFFAOYSA-N

Descripción

Descripción general

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Aplicación

1,1,1-Trichloro-2-methyl-2-propanol hemihydrate (chlorobutanol) is typically used as a preservative in pharmaceutical formulations. It has antimicrobial properties and is active against bacteria and fungi.

Información legal

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

The substance 1.01005 has no REACH registration because the only supported use is the use in medicinal products for human or veterinary use or in food or feedingstuffs according to article 2 of the REACH Regulation (EC) No 1907/2006.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): 212.0 °F - closed cup
• Punto de inflamabilidad (°C): 100 °C - closed cup