1.00286

L-Glutamina

EMPROVE^® EXPERT, DAB, JP, USP

• Sinónimos: Ácido L-glutámico 5-amida, Levoglutamida, Ácido (S)-2,5-diamino-5-oxopentanoico
• Fórmula lineal: H₂NCOCH₂CH₂CH(NH₂)CO₂H
• Número de CAS: 56-85-9
• Peso molecular: 146.14
• Beilstein: 1723797
• Número MDL: MFCD00008044
• Código UNSPSC: 12352209
• Número índice de la CE: 200-292-1

Propiedades

• Agency: DAB; JP; USP
• Nivel de calidad: 500
• descripción: EMPROVE^® EXPERT DAB,USP
• Línea del producto: EMPROVE^® EXPERT
• formulario: solid
• potencia: 7500 mg/kg LD₅₀, oral (Rat)
• técnicas: API processing | cocrystal formation: suitable; API processing | salt formation: suitable
• pH: 4.0-6.0 (20 °C, 25 g/L in H₂O)
• mp: 185 °C (dec.) (lit.)
• solubilidad: 100 g/L
• densidad: 1.47 g/cm³ at 20 °C
• densidad aparente: 640 kg/m³
• temp. de almacenamiento: 2-30°C
• cadena SMILES: N[C@@H](CCC(N)=O)C(O)=O
• InChI: 1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1
• Clave InChI: ZDXPYRJPNDTMRX-VKHMYHEASA-N

Descripción

Descripción general

Our SAFC^® portfolio of high-quality products for biopharmaceutical processing withstands strict quality control procedures and is produced according to MQ-500 requirements as defined by the M-Clarity program.

M-Clarity Program

As part of our EMPROVE^® Program, our raw materials are offered with EMPROVE^® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

Acciones bioquímicas o fisiológicas

La L-glutamina es un aminoácido esencial que es un componente crucial de los medios de cultivo donde actúa como una fuente importante de energía para las células en cultivo. La L-glutamina es muy estable en forma de polvo seco y de disolución congelada. En los medios líquidos o las disoluciones de reserva, sin embargo, la L-glutamina se degrada con relativa rapidez. El rendimiento celular óptimo normalmente requiere la suplementación de los medios con L-glutamina antes de su uso.

Nota de análisis

Assay (perchloric acid titration, calculated on dried substance)99.0 - 101.0 %Identity (IR-spectrum)passes testAppearancewhite to almost white, fine powderAppearance of solution (25 g/l; CO₂-free water)clear and colorlessSpec. rotation (α 20/D, 100 g/l, hydrochloric acid 2 mol/l, calc. on dried substance)+31.5 to +33.0Spec. rotation (α 20/D, 40 g/l, water, calc. on dried substance)+6.3 to +7.3pH (25 g/l; CO₂-free water)4.0 - 6.0Chloride (Cl)≤ 200 ppmSulfate (SO₄)≤ 200 ppmHeavy metals (as Pb)≤ 10 ppmCu (Copper)≤ 25 ppmFe (Iron)≤ 10 ppmFe (Iron) (ICP)≤ 10 ppmMn (Manganese)≤ 25 ppmNi (Nickel)≤ 2 ppmZn (Zinc)≤ 130 ppmNH₄ (Ammonium)≤ 0.1 %Ninhydrin - positive substances (TLC)≤ 0.5 %Residual solvents (ICH Q3C)excluded by manufacturing processSulfated ash (600 °C)≤ 0.1 %Loss on drying (105 °C; 3 h)≤ 0.3 %Bacterial endotoxins≤ 2.0 I.U./gElemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).Corresponds to DAB, USP

Información legal

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 13 - Non Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable