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Merck
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Documentos clave

07-398

Sigma-Aldrich

Anti-phospho-NR2B (Ser1303) Antibody

Upstate®, from rabbit

Sinónimos:

Anti-DEE27, Anti-GluN2B, Anti-MRD6, Anti-NMDAR2B, Anti-NR2B, Anti-NR3, Anti-hNR3

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

100

forma del anticuerpo

purified immunoglobulin

tipo de anticuerpo

primary antibodies

clon

polyclonal

reactividad de especies

rat, human, mouse

fabricante / nombre comercial

Upstate®

técnicas

western blot: suitable

isotipo

IgG

Nº de acceso NCBI

NM_000834

Nº de acceso UniProt

Q13224

Condiciones de envío

dry ice

modificación del objetivo postraduccional

phosphorylation (pSer1303)

Información sobre el gen

human ... GRIN2B(2904)
mouse ... Grin2B(14812)
rat ... Grin2B(24410)

Especificidad

Recognizes phospho-NR2B.

Inmunógeno

Peptide corresponding to amino acids 1297-1309 of human phospho-NR2B

Aplicación

Anti-phospho-NR2B (Ser1303) Antibody detects level of phospho-NR2B (Ser1303) & has been published & validated for use in WB.
Research Category
Neuroscience
Research Sub Category
Oxidative Stress

Neurodegenerative Diseases

Calidad

routinely evaluated by immunoblot in a rat brain microsomal protein preparation

Descripción de destino

~180 kDa

Ligadura / enlace

Replaces: 04-1148

Forma física

Format: Purified
Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
Protein A purified

Almacenamiento y estabilidad

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Nota de análisis

Control
Brain tissue

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información legal

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 2

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Substrate-selective and calcium-independent activation of CaMKII by ?-actinin.
Jalan-Sakrikar, N; Bartlett, RK; Baucum, AJ; Colbran, RJ
The Journal of Biological Chemistry null
C Castillo et al.
Neuroscience, 177, 308-320 (2011-01-11)
The involvement of substance P (SP) in neuronal sensitization through the activation of the neurokinin-1-receptor (NK1r) in postsynaptic dorsal horn neurons has been well established. In contrast, the role of SP and NK1r in primary sensory dorsal root ganglion (DRG)
Johanna G Pasek et al.
Molecular and cellular neurosciences, 68, 234-243 (2015-08-10)
Calcium signaling regulates synaptic plasticity and many other functions in striatal medium spiny neurons to modulate basal ganglia function. Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is a major calcium-dependent signaling protein that couples calcium entry to diverse cellular changes. CaMKII activation
M Sheng et al.
Nature, 368(6467), 144-147 (1994-03-10)
Activation of the N-methyl-D-aspartate (NMDA) receptor is important for certain forms of activity-dependent synaptic plasticity, such as long-term potentiation (reviewed in ref. 1), and the patterning of connections during development of the visual system (reviewed in refs 2, 3). Several
Roles of diverse glutamate receptors in brain functions elucidated by subunit-specific and region-specific gene targeting.
Mori, Hisashi and Mishina, Masayoshi
Life Sciences, 74, 329-336 (2003)
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