07-2262

Anti-WNK3 Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: WNK lysine deficient protein kinase 3, serine/threonine-protein kinase WNK3, Protein kinase with no lysine 3, Protein kinase lysine-deficient 3, protein kinase, lysine deficient 3
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• clon: polyclonal
• application: WB
• reactividad de especies: human, mouse
• técnicas: western blot: suitable

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: human, mouse
• técnicas: western blot: suitable
• Nº de acceso NCBI: NP_001002838
• Nº de acceso UniProt: Q9BYP7
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... WNK3(65267)

Descripción

Descripción general

WNK3 is a serine-threonine protein kinase and expressed throughout the nephron, but most commonly at intercellular junctions. In its active state, it is a promoter of NKCC2 and NCC activity. The opposite is true of WNK3 when in an inactive state. WNK3 changes the expression of these transporters in the membrane and is thought to be a regulator of blood pressure along with other members of the WNK family of protein kinases. In recent research, WNK3 has also been linked to regulating signaling cascades involved in tumorigenesis.

Especificidad

Other homologies: Rat (74% sequence homology).

Inmunógeno

GST-tagged recombinant protein corresponding to human WNK3.

Aplicación

Research Category
Signaling

Research Sub Category
Developmental Signaling

This WNK3 antibody is validated for use in WB for the detection of the WNK3 protein.

Calidad

Evaluated by Western Blot in HEK293 cell lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected WNK3 on 10 µg of HEK293 cell lysate.

Descripción de destino

~220 kDa observed. Uncharacterized bands appear at ~52 and 60 kDa

Forma física

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Nota de análisis

Control
HEK293 cell lysate

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable