07-2192

Anti-phospho-TBK1 (Ser172) Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: Serine/threonine-protein kinase TBK1, NF-kappa-B-activating kinase, T2K, TANK-binding kinase 1
• Código UNSPSC: 12352203
• eCl@ss: 32160702

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: mouse, human
• reactividad de especies (predicha por homología): rat (based on 100% sequence homology)
• técnicas: western blot: suitable
• Nº de acceso NCBI: NP_037386
• Nº de acceso UniProt: Q9UHD2
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: phosphorylation (pSer172)
• Información sobre el gen: human ... TBK1(29110)

Descripción

Descripción general

TBK, also known as IκB kinase (IKK)-related kinase NAK, belong to the serine/threonine IKK kinase family and is thought to play a role in NF-kappa-B (NF-κB) activation. The NF-κB complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NF-κB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NF-κB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NF-κB inhibition caused by TANK.

Especificidad

This antibody recognizes TBK1 phosphorylated at Ser172.

Inmunógeno

KLH-conjugated linear peptide corresponding to human TBK1 phosphorylated at Ser172.

Aplicación

This phospho-TBK1 antibody is validated for use in WB for the detection of the phospho-TBK1 protein.

Calidad

Evaluated by Western Blot in EGF treated and untreated HEK293 cell lysates.

Western Blot Analysis: 1:1,000 dilution of this antibody detected TBK1 on 10 µg of EGF treated and untreated HEK293 cell lysates.

Descripción de destino

~90 kDa observed

Nota de análisis

Control
EGF treated and untreated HEK293 cell lysates

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable