07-1348

Anti-phospho-PLK1 (Ser137) Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: Polo-like kinase 1, Serine/threonine-protein kinase 13, cell cycle regulated protein kinase, polo (Drosophia)-like kinase, polo like kinase, polo-like kinase (Drosophila), polo-like kinase 1 (Drosophila)
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: human, mouse, rat
• reactividad de especies (predicha por homología): bovine
• técnicas: western blot: suitable
• Nº de acceso NCBI: NP_005021
• Nº de acceso UniProt: P53350
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: phosphorylation (pSer137)
• Información sobre el gen: human ... PLK1(5347)

Descripción

Descripción general

Polo-like Kinase 1 (PLK1) is a serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Expressed PLK protein accumulates to a maximum during the G2 and M phases, declines to a nearly undetectable level following mitosis and throughout G1 phase, and then begins to accumulate again during S phase.

Especificidad

This antibody recognizes phosphorylated PLK1 at Ser137.

Inmunógeno

KLH-conjugated linear peptide corresponding to human phosphoylated PLK1 at and around Ser137.

Aplicación

Detect phospho-PLK1 (Ser137) using this Anti-phospho-PLK1 (Ser137) Antibody validated for use in WB.

Research Category
Signaling

Research Sub Category
Kinases & Phosphatases

Western Blot (SNAP ID) Analysis: 0.5 µg/mL of this antibody detected PLK1 phosphorylated at Ser137 in human placenta tissue lysate.

Calidad

Evaluated by Western Blot in human placenta tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected PLK1 phosphorylated at Ser137 in lambda phosphatase treated and untreated human placenta tissue lysate.

Descripción de destino

68 kDa

Forma física

Affinity purified

Affinity purified rabbit serum in 0.1M Tris-Glycine (pH7.4), 150mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Maintain refrigerated at 2-8°C for up to 12 months.

Nota de análisis

Control
Lambda phosphatase treated and untreated human placenta tissue lysate.

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable