06-520

Anti-Na+/K+ ATPase α-1 Antibody

Upstate^®, from rabbit

• Sinónimos: Anti-CMT2DD
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: purified antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• reactividad de especies: bovine, rat, human
• envase: antibody small pack of 25 μg
• fabricante / nombre comercial: Upstate^®
• técnicas: immunocytochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• isotipo: IgG
• Nº de acceso NCBI: NM_001001586
• Nº de acceso UniProt: P05023
• Condiciones de envío: ambient
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: rat ... Atp1A1(24211)

Descripción

Descripción general

Na+/K+ ATPase α-1 is a human gene and functions to maintain Na+ and K+ across the cell membrane which is important for osmoregulation. It is a component of (Na+/K+) ATPase, a transporter that catalyzes the hydrolysis of ATP and transports sodium and potassium ions across the plasma membrane. It also partners with Src and other signaling proteins. Binding of ouabain and other cardiotonic steroids to the (Na+/K+) ATPase activates Src, resulting in the assembly and activation of multiple signaling cascades. Binding of ouabain also induces a positive inotropic effect. Diseases associated with ATPase are Thyrotoxic periodic paralysis and hyperthyroidism. (References: Wikipedia and http://www.bioportfolio.com/gene/476-ATP1A1.html)

Especificidad

Expected to cross-react with Rat-100%, Mouse-99%; human, pig, rabbit, monkey-96%.

Recognizes the α-1 subunit isoform of Na⁺/K⁺ ATPase.

Inmunógeno

Epitope: Cytoplasmic domain

GST-tagged ATPase.

Aplicación

Research Category
Neuroscience

Research Sub Category
Ion Channels & Transporters

This Anti-Na+/K+ ATPase α-1 Antibody is validated for use in IC, IP, WB for the detection of Na+/K+ ATPase α-1.

Calidad

Routinely evaluated by Immunoprecipitation on rat brain microsomal prep. lysate.

Descripción de destino

112 kDa

Forma física

Format: Purified

Protein A purified

Purified antibody in buffer containing 0.1M Tris-Glycine (pH7.4) 150mM NaCl and 0.05% NaN3.

Almacenamiento y estabilidad

Stable for 1 year at 2-8ºC from date of receipt.

Nota de análisis

Control
Rat Brain Microsomal Prep. lysate.

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información legal

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.