06-1334

Anti-phospho-TAB1 (Thr431) Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: TGF-beta activated kinase 1/MAP3K7 binding protein 1, TAK1-binding protein 1, transforming growth factor beta-activated kinase-binding protein 1, mitogen-activated protein kinase kinase kinase 7 interacting protein 1, Mitogen-activated protein kinase kin
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: rat, human, horse, mouse
• reactividad de especies (predicha por homología): equine (based on 100% sequence homology), ox (based on 100% sequence homology)
• técnicas: western blot: suitable
• Nº de acceso NCBI: NP_006107
• Nº de acceso UniProt: Q15750
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: phosphorylation (pThr431)
• Información sobre el gen: human ... TAB1(10454)

Descripción

Descripción general

TAK1 binding protein 1 (TAB1) is thought to activate TAK1 MAPKKK in transforming growth factor-beta (TGF-beta) signaling. TAB1 can also associate with TAK1 to form a unique MAPKKK complex that is thought to activate AP-1 and the NFkappaB signaling pathways. Through conformational changes, TAB1 is also thought to induce p38alpha autophosphorylation. It has been linked to both IL-1alpha and TNFalpha signaling and therefore may also be involved in the inflammatory response. Recent research has found that the TAK1-TAB1 complex may have anti-inflammatory effects by aiding stercurensin in regulating the NFκB-dependent inflammatory pathways.

Especificidad

This antibody recognizes TAB1 phosphorylated at Thr431.

Inmunógeno

Epitope: Phosphorylated Thr431

KLH-conjugated linear peptide corresponding to human TAB1 phosphorylated at Thr431.

Aplicación

Research Category
Inflammation & Immunology

Research Sub Category
Immunoglobulins & Immunology

This Anti-phospho-TAB1 (Thr431) Antibody is validated for use in WB for the detection of phospho-TAB1 (Thr431).

Calidad

Evaluated by Western Blot in L6 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected TAB1 on 10 µg of L6 cell lysate.

Descripción de destino

~78 kDa observed. 55 kDa calculated. A higher molecular weight on western blot may be due to glycosylation. An uncharacterized band appears at ~42 and 50 kDa in some lysates.

Forma física

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Nota de análisis

Control
L6 cell lysate

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable