05-466
Anti-GRK 4-6 Antibody, clone A16/17
clone A16/17, Upstate®, from mouse
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
clon:
A16/17, monoclonal
application:
IP
WB
WB
reactividad de especies:
mouse, human, rat
técnicas:
immunoprecipitation (IP): suitable
western blot: suitable
western blot: suitable
citations:
17
Productos recomendados
origen biológico
mouse
Nivel de calidad
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
A16/17, monoclonal
reactividad de especies
mouse, human, rat
fabricante / nombre comercial
Upstate®
técnicas
immunoprecipitation (IP): suitable
western blot: suitable
isotipo
IgG1κ
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
dry ice
modificación del objetivo postraduccional
unmodified
Información sobre el gen
mouse ... Grk4(14772)
Especificidad
GRK 4, GRK 5 and GRK 6
Inmunógeno
GST fusion protein corresponding to residues 463-590 of bovine GRK 5
Aplicación
Anti-GRK 4-6 Antibody, clone A16/17 detects level of GRK 4-6 & has been published & validated for use in IP & WB.
Research Category
Signaling
Signaling
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling
GPCR, cAMP/cGMP & Calcium Signaling
Calidad
routinely evaluated by immunoblot on murine 3T3/A31 RIPA lysate or human K562 cells
Descripción de destino
65-70kDa
Forma física
0.1M Tris-glycine, pH 7.4, 0.15 NaCl with 0.05% sodium azide
Ammonium Sulfate Precipitation
Format: Purified
Almacenamiento y estabilidad
2 years at -20°C
Nota de análisis
Control
Positive Antigen Control: Catalog #12-305, 3T3/A31 lysate. Add 2.5 μL of 2-mercapto-ethanol/100 μL of lysate and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced lysate per lane for minigels.
Positive Antigen Control: Catalog #12-305, 3T3/A31 lysate. Add 2.5 μL of 2-mercapto-ethanol/100 μL of lysate and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced lysate per lane for minigels.
Información legal
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Y Nagayama et al.
The Journal of biological chemistry, 271(17), 10143-10148 (1996-04-26)
Homologous desensitization of G protein-coupled receptors involves agonist-dependent phosphorylation of receptors by G protein-coupled receptor kinases (GRKs). To identify GRK(s) that play a role in homologous desensitization of the thyrotropin (TSH) receptor, thyroid cDNA was amplified by polymerase chain reaction
E R Bychkov et al.
Neurobiology of aging, 29(3), 379-396 (2006-11-28)
Arrestins and G proteins-coupled receptor kinases (GRKs) regulate signaling and trafficking of G protein-coupled receptors. We investigated changes in the expression of arrestins and GRKs in the striatum of patients with Parkinson's disease without (PD) or with dementia (PDD) at
Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies.
Pitcher, J A, et al.
The Journal of Biological Chemistry, 271, 24907-24913 (1996)
Sudipto Das et al.
Pflugers Archiv : European journal of physiology, 464(1), 101-109 (2012-04-25)
Mitochondrial structure and function are central to cell physiology and are mutually interdependent. Mitochondria represent a primary target of the alcohol-induced tissue injury, particularly in the liver, where the metabolic effects of ethanol are predominant. However, the effect of ethanol
Weiwei Wu et al.
PloS one, 15(4), e0232019-e0232019 (2020-04-29)
Parkinson's disease (PD) is a common neurodegenerative disorder which is mostly sporadic but familial-linked PD (FPD) cases have also been found. The first reported gene mutation that linked to PD is α-synuclein (α-syn). Studies have shown that mutations, increased expression
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