05-23-0600

Substance P

Neuropeptide found in high concentrations in the gut.

• Sinónimos: Substance P, Neurokinin P, RPKPQQFFGLM, SP
• Fórmula empírica (notación de Hill): C₆₃H₉₈N₁₈O₁₃S
• Número de CAS: 33507-63-0
• Peso molecular: 1347.63
• Código UNSPSC: 12352202
• NACRES: NA.51

Propiedades

• Nivel de calidad: 100
• Análisis: ≥96% (HPLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• color: white
• solubilidad: 5% acetic acid: 1 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• InChI: 1S/C63H98N18O13S/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1
• Clave InChI: ADNPLDHMAVUMIW-CUZNLEPHSA-N

Descripción

Descripción general

Substance P (SP) is an 11-amino acid neuropeptide belonging to the tachykinin (TAC) family of neuropeptides. It is encoded by the TAC1 gene in the central nervous system (CNS), the peripheral nervous system, and immune cells. Moreover, it serves essential functions in inflammation, angiogenesis, and wound healing. It is also found in high concentrations in the gut. When released from afferent nerves, it causes a neurogenic inflammatory response, including mast cell degranulation. It is known to induce Ca2+ mobilization and reported to activate Goα, Gq/11α, and Gsα subunits in CHO cells via activation of substance P receptors. Also reported to induce superoxide production in neutrophils.

Aplicación

Substance P (SP) has been used to enhance the lipid accumulation in 3T3‑L1 cells as they undergo differentiation into adipocytes in the presence of elevated glucose levels.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
Substance P receptors

Product does not compete with ATP.

Reversible: no

Envase

Yes

Advertencia

Toxicity: Standard Handling (A)

Secuencia

H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH₂

Forma física

Supplied as a trifluoroacetate salt.

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Roush, E.D., and Kwatra, M.M. 1998. FEBS Lett. 428, 291.
Chiwakata, C.B., et al. 1996. Infect. Immun. 64, 5106.
Tanabe, T., et al. 1996. Eur. J. Pharmacol. 299, 187.
Heath, M.J., et al. 1994. J. Neurophysiol. 72, 1192.
Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
Garland, A.M., et al. 1993. Soc. Neurosci. 19, Abstract 104.6.
Wei, J.Y., et al. 1993. Soc. Neurosci. 19, Abstract 136.14.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable