05-1059

Anti-phospho-p38α(Thr180/Tyr182) Antibody, clone 8.78.8, rabbit monoclonal

culture supernatant, clone 8.78.8, from rabbit

• Sinónimos: CSAID-binding protein, Csaids binding protein, Cytokine suppressive anti-inflammatory drug-binding protein, MAP kinase MXI2, MAP kinase p38 alpha, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, cytokine suppressive anti-inflammato
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: culture supernatant
• tipo de anticuerpo: primary antibodies
• clon: 8.78.8, monoclonal
• reactividad de especies: human, vertebrates, mouse
• técnicas: immunofluorescence: suitable; western blot: suitable
• isotipo: IgG
• Nº de acceso NCBI: NP_001306
• Nº de acceso UniProt: Q15759
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: phosphorylation (pThr180/pTyr182)
• Información sobre el gen: human ... MAPK14(1432)

Descripción

Descripción general

The p38 family refers to the SAPK2/3 Kinases (Stess-Activated Protein Kinases), a subfamily of JNK/SAPK family. p38/SAPK Kinases are also activated by stresses, most notably inflammatory cytokines, irradiation, and certain toxins such as anisomycin and arsenite. SAPKs have been implicated in many pathological conditions, including inflammation, cancer and neurodegenerative diseases. As with the other MAPK family members (ERK, JNK, p38MAPK, and ERK5), p38 is activated through phosphorylation on both threonine and tyrosine residues at the Thr-X-Tyr dual phosphorylation motif, where X is Gly for p38. Once phosphorylated and active, it then goes on to phosphorylate downstream targets in both the cytoplasm and the nucleus. Some of their main targets of p38 are the kinase MAPKAPK2 and the transcription factor ATF2 that are activated via their phosphorylation.

Especificidad

Predicted to cross-react with many other species based on 100% sequence homology with immunogen.

This antibody detects p38α when phosphorylated on Thr180/Tyr182.

Inmunógeno

Epitope: Phosphorylated Thr180/Tyr182

Synthetic peptide corresponding to amino acids surrounding and including phosphorylated Thr180/Tyr182 of human p38α.

Aplicación

Anti-phospho-p38α(Thr180/Tyr182) Antibody, clone 8.78.8 detects level of phospho-p38α(Thr180/Tyr182) & has been published & validated for use in WB & IF.

Research Sub Category
MAP Kinases

Inflammation & Autoimmune Mechanisms

Calidad

Evaluated by western blot on anisomycin-treated HeLa cell lysate.
Western Blot Analysis: 1:5,000-1:10,000 dilution of this antibody was used to detect p38 phosphorylated on Thr180/Tyr182 in anisomycin-treated HeLa and NIH/3T3 cell lysate.

Descripción de destino

38 kDa

Forma física

Rabbit monoclonal antibody in culture supernatant containing 0.05% sodium azide.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable