S-011

Sibutramine hydrochloride monohydrate

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• Sinónimos: 1-(4-Chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)cyclobutanemethanamine hydrochloride monohydrate, Meridia, Reductil
• Fórmula empírica (notación de Hill): C₁₇H₂₆ClN · HCl
• Número de CAS: 84485-00-7
• Peso molecular: 316.31
• Número CE: 200-659-6
• Número MDL: MFCD04039806
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329824413
• NACRES: NA.24

Propiedades

• grado: certified reference material
• formulario: liquid
• Características: Snap-N-Spike^®/Snap-N-Shoot^®
• envase: ampule of 1 mL
• fabricante / nombre comercial: Cerilliant^®
• concentración: 1.0 mg/mL in methanol (as free base)
• técnicas: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• aplicaciones: clinical testing
• formato: single component solution
• temp. de almacenamiento: −20°C
• cadena SMILES: O.Cl.CC(C)CC(N(C)C)C1(CCC1)c2ccc(Cl)cc2
• InChI: 1S/C17H26ClN.ClH.H2O/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14;;/h6-9,13,16H,5,10-12H2,1-4H3;1H;1H2
• Clave InChI: KFNNPQDSPLWLCX-UHFFFAOYSA-N
• Información sobre el gen: human ... SLC6A2(6530) , SLC6A3(6531) , SLC6A4(6532)

Descripción

Descripción general

Sibutramine, a SNRI and anorectant, was marketed as a treatment for obesity until 2010 when it was removed from the market over concerns of potential adverse cardiovascular side effects. Sold under trade names Reductil, Meridia^®, and Subitrex, this sibutramine Snap-N-Spike^® reference solution is applicable for use in LC/MS or GC/MS applications for clinical toxicology and forensic analysis.

Acciones bioquímicas o fisiológicas

Sibutramine is a serotonin and noradrenaline reuptake inhibitor (SNRI). It is an antiobesity drug, which decreases calorie intake and increases energy expanditure. Sibutramine antagonizes MPTP-induced dopamine depletion in mouse brain.

Información legal

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Meridia is a registered trademark of Abbott Laboratories Corp.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS02,GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H225,H301 + H311 + H331,H370
• Consejos de prudencia: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Clasificaciones de peligro: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Órganos de actuación: Eyes,Central nervous system
• Código de clase de almacenamiento: 3 - Flammable liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): 49.5 °F - closed cup
• Punto de inflamabilidad (°C): 9.7 °C - closed cup