P-909

Acetaminophen-D₄ solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Fórmula empírica (notación de Hill): C₈D₄H₅NO₂
• Número de CAS: 64315-36-2
• Peso molecular: 155.19
• Número CE: 200-659-6
• Código UNSPSC: 41116107
• NACRES: NA.24

Propiedades

• grado: certified reference material
• formulario: liquid
• Características: Snap-N-Spike^®/Snap-N-Shoot^®
• envase: ampule of 1 mL
• fabricante / nombre comercial: Cerilliant^®
• concentración: 100 μg/mL in methanol
• técnicas: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• aplicaciones: forensics and toxicology
• formato: single component solution
• temp. de almacenamiento: −20°C
• cadena SMILES: [2H]c1c([2H])c(NC(C)=O)c([2H])c([2H])c1O
• InChI: 1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)/i2D,3D,4D,5D
• Clave InChI: RZVAJINKPMORJF-QFFDRWTDSA-N

Descripción

Descripción general

A stable-labeled internal standard suitable for quantitation of acetaminophen levels in urine, serum, or plasma by LC/MS or GC/MS for clinical toxicology, isotope dilution methods, P450 studies, and other pharmaceutical research. Acetaminophen, or Paracetamol, is a common over-the-counter COX inhibitor drug used for pain relief and fever reduction.

Aplicación

• Simultaneous determination of acetaminophen and oxycoDonein human plasma by LC-MS/MS and its application to a pharmacokinetic study: Highlights the application of acetaminophen-D₄ as an internal standard in pharmacokinetic studies to ensure accurate measurement of drug levels in plasma, crucial for drug development and therapeutic monitoring (Lu et al., 2018).


• Simultaneous quantification of acetaminophen and five acetaminophen metabolites in human plasma and urine by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry: Demonstrates the use of acetaminophen-D₄ in complex bioanalytical methods for studying drug metabolism and excretion in clinical pharmacology (Cook et al., 2015).


• Application of high-performance liquid chromatography/chemical reaction interface mass spectrometry for the analysis of conjugated metabolites: Discusses a method using deuterated acetaminophen (such as acetaminophen-D₄) to analyze conjugated drug metabolites, enhancing the understanding of drug metabolism pathways (Teffera and Abramson, 1994).


• Acetaminophen production in man after coadministration of acetanilid and phenacetin: A study that possibly uses deuterated compounds like acetaminophen-D₄ to trace metabolic pathways and interactions between multiple analgesics, providing insights into their pharmacokinetic behaviors (Baty and Robinson, 1977).

Información legal

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS02,GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H225,H301 + H311 + H331,H370
• Consejos de prudencia: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Clasificaciones de peligro: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Órganos de actuación: Eyes
• Código de clase de almacenamiento: 3 - Flammable liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): 49.5 °F - closed cup
• Punto de inflamabilidad (°C): 9.7 °C - closed cup