N-079
(R,S)-Norcotinine solution
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Fórmula empírica (notación de Hill):
C9H10N2O
Número de CAS:
Peso molecular:
162.19
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
Productos recomendados
grado
certified reference material
Características
(Snap-N-Spike®)
envase
ampule of 1 mL
fabricante / nombre comercial
Cerilliant®
concentración
1.0 mg/mL in methanol
formato
single component solution
temp. de almacenamiento
−20°C
cadena SMILES
O=C1NC(C2=CN=CC=C2)CC1
InChI
1S/C9H10N2O/c12-9-4-3-8(11-9)7-2-1-5-10-6-7/h1-2,5-6,8H,3-4H2,(H,11,12)
Clave InChI
FXFANIORDKRCCA-UHFFFAOYSA-N
Descripción general
Norcotinine, or desmethylcotinine, is a urinary metabolite of nornicotine and cotinine found in smokers and users of other nicotine products including chewing tobacco and snuff. This Certified Spiking Solution® is suitable for use in nicotine testing methods or clinical and diagnostic testing of nicotine biomarkers by LC-MS/MS or GC/MS.
Información legal
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
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Referencia del producto
Descripción
Precios
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Órganos de actuación
Eyes
Código de clase de almacenamiento
3 - Flammable liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
49.5 °F
Punto de inflamabilidad (°C)
9.7 °C
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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N Eldirdiri et al.
European journal of drug metabolism and pharmacokinetics, 22(4), 385-390 (1998-03-26)
Since norcotinine and 4-(3-pyridyl)-4-oxobutyramide (POBAM) are probable metabolites of nicotine and cotinine, it was of interest to investigate the further in vitro metabolism of these compounds. We now report our preliminary findings using rat microsomal preparations (induced and/or non-induced with
P A Crooks et al.
Drug metabolism and disposition: the biological fate of chemicals, 25(1), 47-54 (1997-01-01)
The time course of nicotine metabolite appearance in brain from 5 min-18 hr after subcutaneous administration of S-(-)-[3H-N-methyl]nicotine was determined. Results demonstrated that metabolite appearance in brain was greatest at 4 hr postadministration, whereas levels of nicotine were greatly diminished
Diaa M Shakleya et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(29), 3537-3542 (2009-09-15)
An LC-MS/MS method for the simultaneous quantification of nicotine, cotinine, trans-3'-hydroxycotinine and norcotinine in human plasma was developed and fully validated. Potential endogenous and exogenous interferences were extensively evaluated and limits of quantification were determined by decreasing analyte concentration. Analytical
Diaa M Shakleya et al.
Analytical and bioanalytical chemistry, 395(7), 2349-2357 (2009-10-20)
An analytical procedure was developed and validated for the simultaneous identification and quantification of nicotine, cotinine, trans-3'-hydroxycotinine, and norcotinine in 0.5 mL of human oral fluid collected with the Quantisal oral fluid collection device. Solid phase extraction and liquid chromatography-tandem
H Foth et al.
Toxicology and applied pharmacology, 105(3), 382-392 (1990-09-15)
Elimination parameters of [14C]nicotine in conscious rats receiving nicotine (0.3 mg/kg) either intravenously or orally were studied. The oral availability of unchanged nicotine, derived by comparison of the respective areas under the concentration vs time curves (AUC), was 89%, indicating
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