D-068

Duloxetine-D₃ hydrochloride solution

100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• Fórmula empírica (notación de Hill): C₁₈D₃H₁₆NOS · HCl
• Peso molecular: 336.89
• Número CE: 200-659-6
• Número MDL: MFCD09752117
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329798627
• NACRES: NA.24

Propiedades

• grado: certified reference material
• Nivel de calidad: 300
• Formulario: liquid
• Características: Snap-N-Spike^®/Snap-N-Shoot^®
• envase: ampule of 1 mL
• fabricante / nombre comercial: Cerilliant^®
• concentración: 100 μg/mL in methanol (as free base)
• técnicas: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• aplicaciones: clinical testing
• Formato: single component solution
• temp. de almacenamiento: −20°C
• cadena SMILES: Cl.[2H]C([2H])([2H])NCC[C@H](Oc1cccc2ccccc12)c3cccs3
• InChI: 1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1/i1D3;
• Clave InChI: BFFSMCNJSOPUAY-HQKLNPQUSA-N

Descripción

Descripción general

A stable-labeled internal standard suitable for numerous GC/MS and LC/MS applications from clinical toxicology and urine drug testing to forensic analysis and isotope dilution methods. Duloxetine, marketed in the US under the trade name Cymbalta^®, is a serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder and to alleviate pain associated with diabetic neuropathy, fibromyalgia, and osteoarthritis.

Aplicación

• Rapid Structure-Based Screening for COVID-19: Duloxetine-D₃ hydrochloride solution plays a key role in rapid structure-based screening, potentially informing the development of therapeutic agents for COVID-19 due to its properties as a serotonin-norepinephrine reuptake inhibitor, crucial for high-impact pharmaceutical research (Yang et al., 2020).


• UV-Triggered Drug Release: The high-purity Duloxetine-D₃ solution enhances UV-triggered drug release studies from mesoporous titanium nanoparticles loaded with pharmaceutical agents, indicating significant benefits for developing controlled drug delivery systems in biotechnological applications (Zuo et al., 2024).


• Antioxidant Activity and Eczema Treatment: Duloxetine-D₃ HCl serves as an internal standard in studies evaluating the antioxidant activities and therapeutic applications of drug-loaded liposomes for eczema treatment, highlighting its role in enhancing bioanalytical assay development (Shen et al., 2024).


• Synthesis and Application of EGFR Inhibitors for Cancer: As a stable isotope-labeled compound, Duloxetine-D₃ hydrochloride is used in the synthesis and clinical application studies of small-molecule EGFR inhibitors, underlining its critical application in cancer therapy research (Wang et al., 2024).


• Nanoparticle Drug Release Behaviors: The solution′s role in studying poly(lactic-co-glycolic acid) nanoparticles highlights its utility in pharmaceutical-grade calibration for analyzing hydrophilic and hydrophobic drug release behaviors, essential for pharmaceutical and biomedical research (Wang et al., 2024).

Información legal

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Cymbalta is a registered trademark of Eli Lilly and Co.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS02,GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H225,H301 + H311 + H331,H370
• Consejos de prudencia: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Clasificaciones de peligro: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Órganos de actuación: Eyes
• Código de clase de almacenamiento: 3 - Flammable liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): 49.5 °F - closed cup
• Punto de inflamabilidad (°C): 9.7 °C - closed cup