A-144

Acylcarnitines Mix 2 (C4,iC4,C5,iC5,C6,C8,C10,C12,C14,C18) solution

100-200 μg/mL (90:10 Methanol: 1% aqueous formic acid), certified reference material, ampule of 1 mL, Cerilliant^®

• Sinónimos: Acylcarnitines Mix 2 Solution
• Fórmula empírica (notación de Hill): C₂₅H₄₉NO₄
• Peso molecular: 427.66
• Código UNSPSC: 41116107
• NACRES: NA.24

Propiedades

• grado: certified reference material
• Nivel de calidad: 300
• formulario: liquid
• Características: Snap-N-Spike^®/Snap-N-Shoot^®
• composición: Butyryl-L-carnitine, 100 μg/mL ; Decanoyl-L-carnitine, 100 μg/mL ; Hexanoyl-L-carnitine, 100 μg/mL ; Isobutyryl-L-carnitine, 100 μg/mL ; Isovaleryl-L-carnitine, 100 μg/mL ; Lauroyl-L-carnitine, 100 μg/mL ; Myristoyl-L-carnitine, 100 μg/mL ; Octanoyl-L-carnitine, 100 μg/mL ; Stearoyl-L-carnitine, 200 μg/mL ; Valeryl-L-carnitine, 100 μg/mL
• envase: ampule of 1 mL
• fabricante / nombre comercial: Cerilliant^®
• concentración: 100-200 μg/mL (90:10 Methanol: 1% aqueous formic acid)
• técnicas: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• aplicaciones: clinical testing
• formato: multi-component solution
• temp. de almacenamiento: −70°C

Descripción

Descripción general

A Certified Spiking Solution^® of routinely tested Butyryl-L-Carnitine, Isobutyryl-L-Carnitine, Valeryl-L-Carnitine, Isovaleryl-L-Carnitine, Hexanoyl-L-Carnitine, Octanoyl-L-Carnitine, Decanoyl-L-Carnitine, Lauroyl-L-Carnitine, Myristoyl-L-Carnitine and Stearoyl-L-Carnitine at concentrations of 100-200 μg/mL. Acylcarnitines are biomarker for many inborn errors of metabolism that cause several metabolic diseases and are routinely tested in newborn screening programs. This multi-component mix is suitable for critical quantitative applications in research and clinical environments including: for use in preparation of controls, calibrators, and linearity standards for LC-MS/MS assays; as system tuning/suitability standards; linearity verification; and internal proficiency testing. The stable, quantitative solution format provides significant benefits to the user such as convenience of use, material savings, and increased efficiency of labor. Certified concentration values for each component provides increased efficiency from less time remaking pools due to dilution errors or rerunning samples.

Aplicación

• Metabolic Disorder Biomarker Development: Acylcarnitines are crucial in diagnosing very long-chain acyl-CoA dehydrogenase deficiency. This research utilizes acylcarnitine profiles to improve understanding and treatment approaches for metabolic disorders, employing mass spectrometry metabolites for precise analysis (Bleeker JC et al., 2020).


• High-Purity Acylcarnitine Standards in Research: The study demonstrate the simultaneous extraction of metabolomes and lipidomes, including acylcarnitines, using ultra-high performance liquid chromatography/mass spectrometry. This methodology supports high-precision studies in fatty acid oxidation and metabolic assay development (Chen S et al., 2013).


• Application in Inborn Errors of Metabolism Assay: The research investigates how dietary bioactive polyphenols affect the mitochondrial carnitine acylcarnitine carrier, showcasing the utility of acylcarnitines in studying the impact of natural compounds on metabolic pathways, vital for understanding inborn errors of metabolism (Console L et al., 2019).

Información legal

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS02,GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H225,H301 + H311 + H331,H370
• Consejos de prudencia: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Clasificaciones de peligro: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Órganos de actuación: Eyes,Central nervous system
• Código de clase de almacenamiento: 3 - Flammable liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): 49.5 °F - closed cup
• Punto de inflamabilidad (°C): 9.7 °C - closed cup