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840513P

Avanti

18:1 Phosphatidylethanol

1,2-dioleoyl-sn-glycero-3-phosphoethanol (sodium salt), powder

Sinónimos:

1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanol (sodium salt)

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About This Item

Fórmula empírica (notación de Hill):
C41H76O8PNa
Número de CAS:
322647-53-0
Peso molecular:
751.00
Código UNSPSC:
12352211
NACRES:
NA.25

Análisis

>99% (TLC)

formulario

powder

envase

pkg of 1 × 25 mg (840513P-25mg)

fabricante / nombre comercial

Avanti Research™ - A Croda Brand 840513P

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

cadena SMILES

[H][C@@](COP([O-])(OCC)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Na+]

InChI

1S/C41H77O8P.Na/c1-4-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-40(42)46-37-39(38-48-50(44,45)47-6-3)49-41(43)36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-5-2;/h19-22,39H,4-18,23-38H2,1-3H3,(H,44,45);/q;+1/p-1/b21-19-,22-20-;/t39-;/m1./s1

Clave InChI

AHVVHDCFEFPKMN-AOEFFCPUSA-M

Descripción general

18:1 Phosphatidylethanol (PEth)/1,2-dioleoyl-sn-glycero-3-phosphoethanol is a sodium salt of modified lipid, wherein C-1, C-2 of glycerol is substituted with 9Z-octadecenolyl and C-3 of glycerol is substituted by phosphoethanol group. This lipid metabolite of ethanol has two oleic acid chains.

Aplicación

18:1 Phosphatidylethanol (PEth)/1,2-dioleoyl-sn-glycero-3-phosphoethanol may be used:
  • as a standard in liquid chromatography−mass spectrometry (LC-MS) analysis of PEth in human whole blood
  • as a reference material in quantifying phosphatidylethanol in human blood by liquid chromatography high resolution mass spectrometry (LC−HRMS )
  • to incorporate into human high density lipoprotein (HDL) particles to study its effects on the secretion of vascular endothelial growth factor (VEGF) in cultured human smooth muscle cells

Acciones bioquímicas o fisiológicas

Phosphatidylethanol (PEth) obtained from phosphatidylcholine in erythrocytes can acts as an important biomarker for alcohol consumption.

Envase

5 mL Clear Glass Sealed Ampule (840513P-25mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Código de clase de almacenamiento

11 - Combustible Solids

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Xiaoyu Liang et al.
Molecular psychiatry (2020-02-09)
The process of diagnosing hazardous alcohol drinking (HAD) is based on self-reported data and is thereby vulnerable to bias. There has been an interest in developing epigenetic biomarkers for HAD that might complement clinical assessment. Because alcohol consumption has been
Marja K Liisanantti et al.
Atherosclerosis, 180(2), 263-269 (2005-05-25)
To study whether qualitative changes in high density lipoprotein (HDL) phospholipids mediate part of the advantageous effects of ethanol on atherosclerosis, we investigated whether HDL associated phosphatidylethanol (PEth) affects the secretion of vascular endothelial growth factor (VEGF) from cultured human
Alessandro Nalesso et al.
Journal of chromatography. A, 1218(46), 8423-8431 (2011-10-18)
Phosphatidylethanol (PEth) is a group of aberrant phospholipids formed in cell membranes in the presence of ethanol by the catalytic action of the enzyme phospholipase D on phosphatidylcholine. Recently published literature has demonstrated the existence of several molecular species of
Siming Wang et al.
Talanta, 166, 315-320 (2017-02-19)
Phosphatidylethanol (PEth) is a special phospholipid that is only formed in the presence of ethanol, and therefore, serves as a promising biomarker for alcohol intake. In this study, a simple, rapid and precise method based on LC-MS/MS combined with ultrasound-assisted

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