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830865P

Avanti

18:0 PA

Avanti Research™ - A Croda Brand

Sinónimos:

1,2-dioctadecanoyl-sn-glycero-3-phosphate (sodium salt); DSPA; PA(18:0/18:0)

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About This Item

Fórmula empírica (notación de Hill):
C39H76O8PNa
Número de CAS:
108321-18-2
Peso molecular:
726.98
Número MDL:
MFCD00153888
Código UNSPSC:
51191904
NACRES:
NA.25

descripción

1,2-distearoyl-sn-glycero-3-phosphate (sodium salt)

Ensayo

>99% (TLC)

Formulario

powder

envase

pkg of 1 × 25 mg (830865P-25mg)
pkg of 1 × 500 mg (830865P-500mg)

fabricante / nombre comercial

Avanti Research™ - A Croda Brand

tipo de lípido

cardiolipins
phospholipids

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

cadena SMILES

[Na+].[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC)O

InChI

1S/C39H77O8P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(40)45-35-37(36-46-48(42,43)44)47-39(41)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h37H,3-36H2,1-2H3,(H2,42,43,44);/q;+1/p-1/t37-;/m1./s1

Clave InChI

ALPWRKFXEOAUDR-GKEJWYBXSA-M

Descripción general

Phosphatidic acid (PA) has two fatty acids and one phosphate group attached to a glycerol backbone. The two fatty acids are present at position sn-1 and sn-2 of the C-atoms and the phosphate group is present in the sn-3 position of the C-atom.

Aplicación

18:0 PA may be used:
  • as a component in the bilayer to study its vesiculation ability on different coat protein I (COPI) fission factor
  • to study its effects on intracellular Ca2+ concentration ([Ca2+]i) in C6 rat glioma and L2071 mouse fibroblast cells
  • to study its effects on phosphorylation of cytochrome b(558) alpha chain (p22phox)

Acciones bioquímicas o fisiológicas

Phosphatidic acid (PA) acts as a biosynthetic precursor for the production of membrane glycerophospholipid and triacylglycerol. It participates in the modulation of mammalian target of rapamycin (mTOR) pathway. It may also participate in membrane trafficking, specifically in membrane fusion and fission.

Envase

20 mL Clear Glass Screw Cap Vial (830865P-500mg)
5 mL Amber Glass Screw Cap Vial (830865P-25mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

también adquirido normalmente con este producto

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

13 - Non Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Yang Liu et al.
Nature communications, 10(1), 5108-5108 (2019-11-11)
Mounting evidence suggests that the tumor microenvironment is profoundly immunosuppressive. Thus, mitigating tumor immunosuppression is crucial for inducing sustained antitumor immunity. Whereas previous studies involved intratumoral injection, we report here an inhalable nanoparticle-immunotherapy system targeting pulmonary antigen presenting cells (APCs)
Seung-Yeol Park et al.
Nature communications, 10(1), 3409-3409 (2019-08-01)
Studies on vesicle formation by the Coat Protein I (COPI) complex have contributed to a basic understanding of how vesicular transport is initiated. Phosphatidic acid (PA) and diacylglycerol (DAG) have been found previously to be required for the fission stage
Qiang Cheng et al.
Nature nanotechnology, 15(4), 313-320 (2020-04-07)
CRISPR-Cas gene editing and messenger RNA-based protein replacement therapy hold tremendous potential to effectively treat disease-causing mutations with diverse cellular origin. However, it is currently impossible to rationally design nanoparticles that selectively target specific tissues. Here, we report a strategy

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