830843P

10:0 PA

1,2-didecanoyl-sn-glycero-3-phosphate (sodium salt), powder

• Sinónimos: PA(10:0/10:0)
• Fórmula empírica (notación de Hill): C₂₃H₄₄O₈PNa
• Número de CAS: 321883-64-1
• Peso molecular: 502.55
• Código UNSPSC: 51191904
• NACRES: NA.25

Propiedades

• Ensayo: >99% (TLC)
• Formulario: powder
• envase: pkg of 1 × 25 mg (830843P-25mg); pkg of 1 × 500 mg (830843P-500mg)
• fabricante / nombre comercial: Avanti Research^™ - A Croda Brand 830843P
• tipo de lípido: cardiolipins; phospholipids
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• cadena SMILES: [H][C@@](COP([O-])(O)=O)(OC(CCCCCCCCC)=O)COC(CCCCCCCCC)=O.[Na+]
• InChI: 1S/C23H45O8P.Na/c1-3-5-7-9-11-13-15-17-22(24)29-19-21(20-30-32(26,27)28)31-23(25)18-16-14-12-10-8-6-4-2;/h21H,3-20H2,1-2H3,(H2,26,27,28);/q;+1/p-1/t21-;/m1./s1
• Clave InChI: YVHWEENUNNUSBE-ZMBIFBSDSA-M

Descripción

Descripción general

Phosphatidic acid (PA), a minor constituent of biological membranes is a simplest glycerophospholipid. It has glycerol backbone with phosphate present at C-3 position. The C-1 and C-2 positions are esterified with fatty acids.

Aplicación

10:0 PA may be used:

• as a component in the lipid bilayer to study how lipid geometry acts in coat protein I (COPI) vesicle fission
• to study its effects on intracellular Ca²⁺ concentration ([Ca²⁺]i) in C6 rat glioma and L2071 mouse fibroblast cells
• to activate protein kinase C (PKC)
• as a cell-free activator in membrane and cytosolic fractions for nicotinamide adenine dinucleotide phosphate (NADPH) oxidase assay

Acciones bioquímicas o fisiológicas

Phosphatidic acid (PA) serves as a lipid second messenger. It can control membrane shape. It is known to participate in cell proliferation, vesicular trafficking, cytoskeletal organization and signal transduction. PA can stimulate negative curvature in lamellar lipid structures. It can block the enzymatic activity of protein phosphatase 1 (PP1).

Envase

30 mL Amber Wide Mouth Bottle with Screw Cap (830843P-500mg)

5 mL Clear Glass Sealed Ampule (830843P-25mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids