700052P
Avanti
22(R)-hydroxycholesterol-d7
Avanti Research™ - A Croda Brand
Sinónimos:
25,26,26,26,27,27,27-heptadeuterocholest-5-ene-3β,22R-diol
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About This Item
Productos recomendados
descripción
cholest-5-ene-3β,22(R)-diol-d7
Análisis
>99% (TLC)
formulario
powder
envase
pkg of 1 × 1 mg (700052P-1mg)
fabricante / nombre comercial
Avanti Research™ - A Croda Brand
aplicaciones
lipidomics
metabolomics
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
Descripción general
22(R)-hydroxycholesterol is a diastereomer of 22(S)-hydroxycholesterol. It is present in the neonate brain. 22(R)-hydroxycholesterol-d7 is a deuterated form of 22(R)-hydroxycholesterol.
Acciones bioquímicas o fisiológicas
22(R)-hydroxycholesterol (22(R)-HC) is a liver X receptor (LXR) ligand and is a key for the receptor activation.. 22(R)-HC promotes mesenchymal stem cell osteogenesis along with other oxysterols. It also regulates cholesterol homeostasis and suppresses prostate tumor progression. Low levels of 22(R)-HC is observed in Alzheimer′s disease and may be implicated in neuroinflammation and neurodegenerative diseases.
Envase
5 mL Amber Glass Screw Cap Vial (700052P-1mg)
Información legal
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Código de clase de almacenamiento
11 - Combustible Solids
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Previously, we and other groups reported that liver X receptor (LXR) agonists T0901317, 22(R)-hydroxycholesterol, and 24(S)-hydroxycholesterol suppressed the proliferation of prostate and breast cancer cells. In this study, we report that T0901317 and 22(R)-hydroxycholesterol treatment inhibited the proliferation of different
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