700047P

5α,6α-epoxycholestanol-d7

Avanti Polar Lipids

• Sinónimos: cholestanol, 5α,6α-epoxy-d7
• Fórmula empírica (notación de Hill): C₂₇H₃₉O₂D₇
• Número de CAS: 127685-38-5
• Peso molecular: 409.70
• Código UNSPSC: 12352100
• NACRES: NA.25

Propiedades

• Análisis: >99% (TLC)
• formulario: powder
• envase: pkg of 1 × 1 mg (700047P-1mg)
• fabricante / nombre comercial: Avanti Polar Lipids
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C

Descripción

Descripción general

5α,6α-epoxycholestanol (5α,6α-EC) is generated by cholesterol epoxidation. 5α,6α-epoxycholestanol-d7 is a deuterated derivative of 5α,6α-EC. It is catabolized by the enzyme cholesterol-5,6-epoxide hydrolase (ChEH) enzyme to 3β,5α,6β-triol.

Aplicación

5α,6α-epoxycholestanol-d7 has been used as an internal standard in isotope dilution-mass spectrometry analysis of heart mitochondrial samples. It may be used as an internal standard in liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis of plasma samples.

Acciones bioquímicas o fisiológicas

5α,6α-epoxycholestanol (5α,6α-EC) is a liver X receptor (LXR) antagonist. 5α,6α-EC is employed in anticancer treatments. It impairs redox state and affects atherogenesis. The levels of 5α,6α-EC are elevated in hypercholesterolemia. It mediates steroid receptor coactivator (SRC) recruitment.

Envase

5 mL Amber Glass Screw Cap Vial (700047P-1mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids