QBD10852

dPEG^®₁₂-SATA (S-acetyl-dPEG^®₁₂-NHS ester)

• Sinónimos: alpha-[2-(acetylthio)ethyl]-omega-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropoxy]poly(oxy-1,2-ethanediyl)
• Fórmula empírica (notación de Hill): C₃₃H₅₉NO₁₇S
• Número de CAS: 1334169-95-7
• Peso molecular: 773.88
• Número MDL: MFCD21363255
• Código UNSPSC: 12352108
• ID de la sustancia en PubChem: 329823963
• NACRES: NA.22

Propiedades

• Análisis: >90%
• formulario: solid or viscous liquid
• idoneidad de la reacción: reagent type: chemical modification reagent; reagent type: cross-linking reagent; reactivity: amine reactive
• arquitectura del polímero: shape: linear; functionality: monofunctional
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• cadena SMILES: O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCSC(C)=O)ON1C(CCC1=O)=O

Descripción

Características y beneficios

dPEG^®₁₂-SATA (S-acetyl-dPEG^®₁₂-NHS ester) contains an acetyl-protected thiol on one end of a single molecular weight dPEG^® linker and an amine-reactive N-hydroxysuccinimide (NHS) ester on the other end. One or more free primary amines on the target molecule can be reacted with dPEG^®₁₂-SATA to install a protected thiol connected to the molecule via the dPEG^® linker. Three different linker lengths provide precise distance control between the target molecule and the acetyl-protected thiol group. The dPEG^® linker imparts water solubility and reduced immunogenicity to the target molecule. Compared to reagents containing only hydrocarbon spacers, dPEG^®-containing reagents also reduce aggregation and precipitation of crosslinked proteins. The acetyl group is easily removed by mild chemical deprotection with hydroxylamine hydrochloride, exposing the free thiol, which can then be used to form a disulfide or thiol ether bond to another molecule. Although commonly used with proteins, these reagents are also suitable for any small molecules or peptides with suitable functionalities.

Información legal

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable