QBD10011

Phthalimidooxy-dPEG^®₄-NHS ester

• Fórmula empírica (notación de Hill): C₂₃H₂₈N₂O₁₁
• Peso molecular: 508.48
• Número MDL: MFCD28155511
• Código UNSPSC: 12352108
• ID de la sustancia en PubChem: 329823874
• NACRES: NA.22

Propiedades

• Análisis: >90%
• formulario: solid or viscous liquid
• idoneidad de la reacción: reactivity: amine reactive; reagent type: cross-linking reagent; reactivity: thiol reactive
• grupo funcional: NHS ester
• arquitectura del polímero: shape: linear; functionality: heterobifunctional
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• cadena SMILES: O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCON2C(C(C=CC=C3)=C3C2=O)=O

Descripción

Características y beneficios

Phthalimidooxy-dPEG^®₄-NHS ester allows introduction of an oxyamine function onto a target molecule for cross-linking proteins or for creating stable conjugates with the target molecule. The oxyamine function is protected by a phthalimido protecting group on one end of the spacer arm, and the spacer is installed on the target molecule with the amine-reactive N-hydroxysuccinimide (NHS) group on the other end of the spacer. The single molecular weight dPEG^® spacers have precise length for spatial control. They are hydrophilic and non-immunogenic. The dPEG^® spacers improve water solubility and reduce aggregation and precipitation of proteins. The phthalimido protecting group can be removed using hydrazine. The oxyamine group exposed after deprotection can be reacted with an aldehyde- or ketone-containing molecule to form an oxime bond linking the two molecules. These reagents can be used with any protein, peptide, or small molecule that has a free amine.

Información legal

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable