L021000

Desbloqueo DCA

with Dichloromethane

• Código UNSPSC: 41116004
• NACRES: NA.21

Propiedades

• tpo: for DNA synthesis; for DNA synthesis
• Línea del producto: Proligo Reagents
• formulario: liquid
• condiciones de almacenamiento: dry at room temperature
• concentración: 42.2-51.6 g/L (DCA content, titration)
• impurezas: ≤200 ppm water content (Karl Fischer)
• color: clear

Descripción

Descripción general

Deblock solution contains dichloroacetic acid (DCA) in dichloromethane that assists in the removal of the dimethoxytrityl (DMT) protecting group from the 5′hydroxyl moiety of nucleotides already incorporated into the growing nucleic acid, before the addition of the next phosphoramidite. Removal of the DMT allows the unprotected 5′hydroxyl moiety to react with a new phosphoramidite in a subsequent extension reaction.

Nota de preparación

Dicloromethane / Dichloroacetic acid 97/3 (v/v)

Otras notas

Deblock solution containing dichloroacetic acid (DCA) in dichloromethane removes the dimethoxytrityl (DMT) protecting group from the 5′hydroxyl moiety of nucleotides already incorporated into the growing nucleic acid, prior to the addition of the next phosphoramidite. Removal of the DMT allows the unprotected 5′hydroxyl moiety to react with a new phosphoramidite in a subsequent extension reaction.

Información de seguridad

• Pictogramas: GHS08,GHS05,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H315,H318,H336,H351,H360FD,H362
• Consejos de prudencia: P202 - P263 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Clasificaciones de peligro: Carc. 2 - Eye Dam. 1 - Lact. - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Central nervous system
• Código de clase de almacenamiento: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable