934240

Pomalidomide acetic acid

≥95.0%

• Sinónimos: N-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]glycine
• Fórmula empírica (notación de Hill): C₁₅H₁₃N₃O₆
• Número de CAS: 927670-97-1
• Peso molecular: 331.28
• Número MDL: MFCD31667076
• Código UNSPSC: 12352106
• NACRES: NA.21

Propiedades

• ligand: pomalidomide
• Nivel de calidad: 100
• Análisis: ≥95.0%
• formulario: powder or crystals
• temp. de almacenamiento: 2-8°C

Descripción

Aplicación

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.

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Otras notas

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Información legal

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Pictogramas: GHS08
• Palabra de señalización: Warning
• Frases de peligro: H361d,H373
• Consejos de prudencia: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Clasificaciones de peligro: Repr. 2 - STOT RE 2
• Órganos de actuación: Blood
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable