930075

2-fluoro-6-(pyrimidin-5-yl)aniline

≥95%

• Fórmula empírica (notación de Hill): C₁₀H₈FN₃
• Número de CAS: 1697040-97-3
• Peso molecular: 189.19
• Código UNSPSC: 12352106
• NACRES: NA.06

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95%
• Formulario: powder, crystals or chunks
• color: light yellow
• grupo funcional: fluoro
• temp. de almacenamiento: −20°C
• cadena SMILES: NC1=C(C2=CN=CN=C2)C=CC=C1F
• InChI: 1S/C10H8FN3/c11-9-3-1-2-8(10(9)12)7-4-13-6-14-5-7/h1-6H,12H2

Descripción

Aplicación

2-fluoro-6-(pyrimidin-5-yl)aniline is a temporary directing group (TDG) to assist as a co-catalyst for metal catalyzed C-H functionalization. Often in C-H functionalization, an auxiliary compound is used to control site selectivity. These traditionally are covalently bonded to the compound of interest, and must subsequently be removed after functionalization, like a typical protecting group. To simplify the process of C-H functionalization, 2-fluoro-6-(pyrimidin-5-yl)aniline is one of a series of temporary directing groups developed by Deb Maiti′s lab that promote site selectivity without the inclusion of additional synthetic steps.


2-fluoro-6-(pyrimidin-5-yl)aniline is an effective TDG for meta directed C-H functionalization of aldehyde substituted target compounds, with high selectivity.

Otras notas

1. Imine as a linchpin approach for meta-C–H functionalization2. Transient directing ligands for selective metal-catalysed C–H activation

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable