902691

Hydroxy-PEG5-t-butyl ester

• Sinónimos: tert-Butyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate, HO-PEG5-CO-OtBu
• Fórmula empírica (notación de Hill): C₁₇H₃₄O₈
• Número de CAS: 850090-09-4
• Peso molecular: 366.45
• Número MDL: MFCD20926402
• Código UNSPSC: 51171641

Propiedades

• Análisis: ≥95%
• formulario: liquid
• idoneidad de la reacción: reagent type: cross-linking reagent
• índice de refracción: n/D 1.448
• densidad: 1.071
• grupo funcional: ester; hydroxyl
• temp. de almacenamiento: −20°C
• cadena SMILES: O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCO

Descripción

Aplicación

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Otras notas

Synthesis and Application of Poly(phenylene Ethynylene)s for Bioconjugation: A Conjugated Polymer-Based Fluorogenic Probe for Proteases

Información legal

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable