804568

(R,S)-Bode Kinetic Resolution Catalyst

• Sinónimos: (4aR,9aS)-6-Bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one
• Fórmula empírica (notación de Hill): C₁₁H₁₀BrNO₃
• Número de CAS: 1394957-71-1
• Peso molecular: 284.11
• Código UNSPSC: 12352101
• ID de la sustancia en PubChem: 329768882
• NACRES: NA.22

Propiedades

• formulario: solution
• Nivel de calidad: 100
• temp. de almacenamiento: 15-25°C
• cadena SMILES: O=C(CO1)N(O)[C@@]2([H])[C@]1([H])CC3=CC=C(Br)C=C32
• InChI: 1S/C11H10BrNO3/c12-7-2-1-6-3-9-11(8(6)4-7)13(15)10(14)5-16-9/h1-2,4,9,11,15H,3,5H2/t9-,11+/m0/s1
• Clave InChI: FQXSUQCCAHKURK-GXSJLCMTSA-N

Descripción

Aplicación

The following hydroxamic acid catalyst was shown by Bode and coworkers to assist in the kinetic resolution of cyclic amines through acylation of one enantiomer, which can be controlled using either the (R or S)- or (S or R)-Bode Kinetic Resolution Catalyst, both of which are also available through Sigma-Aldrich.
It can also be employed in the preparation of nonracemic piperidines by kinetic resolution using an α-hydroxy-α′, β-unsaturated ketone in the presence of a pyrrolotriazolium salt.

Otras notas

Expanded substrate scope and catalyst optimization for the catalytic kinetic resolution of N-heterocycles

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P301 + P312 + P330
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable