123323
Quinazoline
99%
Sinónimos:
1,3-Benzodiazine, Benzopyrimidine
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About This Item
Fórmula empírica (notación de Hill):
C8H6N2
Número de CAS:
Peso molecular:
130.15
Beilstein:
109370
Número CE:
Número MDL:
Código UNSPSC:
12352100
ID de la sustancia en PubChem:
NACRES:
NA.22
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Análisis
99%
formulario
solid
bp
243 °C (lit.)
mp
46-48 °C (lit.)
solubilidad
H2O: freely soluble
organic solvents: soluble
cadena SMILES
c1ccc2ncncc2c1
InChI
1S/C8H6N2/c1-2-4-8-7(3-1)5-9-6-10-8/h1-6H
Clave InChI
JWVCLYRUEFBMGU-UHFFFAOYSA-N
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Descripción general
Quinazolines has applications in medicinal chemistry due to their antibacterial, antifungal, anticonvulsant, anti-inflammatory and antitumor activities. It is the basic structural unit of pharmaceuticals and plays an important role in modern synthesis of antitumor drugs.
Aplicación
Quinazoline was used to study the electrochemical behaviour of quinazoline using modern polarographic and voltammetric methods.
Acciones bioquímicas o fisiológicas
Genotoxicity of quinazoline was established by bacterial SOS Chromotest (Escherichia Coli).
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
222.8 °F - closed cup
Punto de inflamabilidad (°C)
106 °C - closed cup
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Zhijiang Fan et al.
Molecular diversity, 22(3), 657-667 (2018-03-27)
A series of structurally novel 3-thioether-1-(quinazolin-4-yl)-1H-1,2,4-triazol-5-amine derivatives (7a-7r) were designed and synthesized based on a pharmacophore hybrid approach, and screened for their antibacterial and antifungal activities in vitro. All the target compounds were fully characterized through [Formula: see text]H NMR
Elham Bagheri et al.
Current pharmaceutical design, 24(13), 1395-1404 (2018-02-01)
Quinazoline is an aromatic bicyclic compound exhibiting several pharmaceutical and biological activities. This study was conducted to investigate the potential wound healing properties of Synthetic Quinazoline Compound (SQC) on experimental rats. The toxicity of SQC was determined by MTT cell
Siva Jyothi Buggana et al.
Computational biology and chemistry, 79, 110-118 (2019-02-21)
Recent studies reported the involvement of JAK2/STAT3 pathway in various solid tumours including breast, ovarian, prostate and lung cancers. Clinical literature also reported the lowered burden in breast and ovarian cancers by targeting JAK2 pathway. In this study, a series
Polarographic and voltammetric determination of quinazoline-the structural unit of anticancer drugs.
Hladikova J, et al.
Sensing in Electroanalysis, 3, 165-175 (2008)
Reddy Amala et al.
BioImpacts : BI, 11(1), 15-22 (2021-01-21)
Introduction: Inflammation is the primary response caused due to harmful stimuli which are followed by the increased draining of plasma and immune cells from the body into the site of the injured tissue. A signaling cascade of growth factors and
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