SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
Sinónimos:
EL2, HPP, HS3, SPH3, SPTA
Especie:
Human SPTA1 (6708), Mouse Spta1 (20739), Rat Spta1 (289257), domestic cat SPTA1 (101097298), Horse SPTA1 (100056575), dog SPTA1 (488616), domestic guinea pig Spta1 (100722803), naked mole-rat Spta1 (101706547), cow SPTA1 (505122), sheep SPTA1 (101112688)
ID UniProtKB:
ID del gen:
- Human(6708) Summary: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008]
- Mouse(20739) spectrin alpha, erythrocytic 1
- Rat(289257) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- domestic cat(101097298) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- Horse(100056575) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- dog(488616) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- domestic guinea pig(100722803) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- naked mole-rat(101706547) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- cow(505122) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
- sheep(101112688) spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
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Antibodies
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Spectrin (RBC2/3D5) Mouse Monoclonal Antibody, ,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-SPTA1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-SPTA1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-SPTA1, affinity isolated antibody,
Reactividad de especies
human, mouse
Aplicación
immunohistochemistry
western blot
western blot
Anti-alpha 1 Spectrin Antibody, clone 1U5K4, Rabbit Monoclonal, ,
Reactividad de especies
human, rat
Aplicación
western blot
Proteins
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esiRNA
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