PPARD
peroxisome proliferator-activated receptor delta
Sinónimos:
FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB
Especie:
Human PPARD (5467), Mouse Ppard (19015), Rat Ppard (25682), chicken PPARD (395479), dog PPARD (481756), Horse PPARD (100053404), domestic cat PPARD (101098383), cow PPARD (353106), sheep PPARD (101117625), domestic guinea pig Ppard (100725136)
ID UniProtKB:
ID del gen:
- Human(5467) Summary: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
- Mouse(19015) peroxisome proliferator activator receptor delta
- Rat(25682) peroxisome proliferator-activated receptor delta
- chicken(395479) peroxisome proliferator-activated receptor delta
- dog(481756) peroxisome proliferator-activated receptor delta
- Horse(100053404) peroxisome proliferator-activated receptor delta
- domestic cat(101098383) peroxisome proliferator-activated receptor delta
- cow(353106) peroxisome proliferator-activated receptor delta
- sheep(101117625) peroxisome proliferator-activated receptor delta
- domestic guinea pig(100725136) peroxisome proliferator-activated receptor delta
- naked mole-rat(101722175) peroxisome proliferator-activated receptor delta
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Small Molecule - Activator
Small Molecule - Agonist
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Especie
Small Molecule - Antagonist
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Especie
Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-PPARδ Antibody, clone 1I8 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human
Aplicación
affinity binding assay
immunocytochemistry
western blot
immunocytochemistry
western blot
Anti-PPARD antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
western blot
Monoclonal Anti-PPARD antibody produced in mouse, clone 1G4, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
ELISA
western blot
western blot
Anti-PPAR δ (Isoform 1) antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reactividad de especies
human
Aplicación
ELISA
western blot
western blot
Anti-Peroxisome Proliferator Activated Receptor δ antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution,
Reactividad de especies
mouse
Aplicación
western blot