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Merck

NOTCH3

notch 3

Sinónimos:
CADASIL, CASIL, IMF2
Especie:
ID UniProtKB:
ID del gen:
  • Human(4854) Summary: This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
  • Mouse(18131) notch 3
  • Rat(56761) notch 3
  • Zebrafish(58066) notch homolog 3
  • dog(610439) notch 3
  • domestic cat(101088469) notch 3
  • cow(789485) notch 3
  • sheep(101123554) notch 3
  • domestic guinea pig(100716867) notch 3
  • naked mole-rat(101722220) notch 3

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ELISA

Referencia del producto
Descripción
Especie
Human Notch-3 ELISA, for serum, plasma and cell culture supernatants,
Especie
human

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-NOTCH 3/N3ECD Antibody, clone 1E4, clone 1E4, 1 mg/mL, from mouse,
Reactividad de especies
human
Aplicación
electron microscopy
immunocytochemistry

western blot
Monoclonal Anti-NOTCH3 antibody produced in mouse, clone 2E2, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
ELISA
immunofluorescence

western blot
Anti-NOTCH3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
Anti-Notch 3 Antibody, clone 1G17 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, mouse, rat
Aplicación
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-NOTCH3 (C-terminal) antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunohistochemistry

western blot

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
DAPT, ≥98% (HPLC), solid,
Especie
mouse, human, rat
L-685,458, >96% (HPLC), solid,
Especie
mouse, human, rat

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting mouse Notch3,
Especie
mouse
MISSION® esiRNA, targeting human NOTCH3,
Especie
human