PHL80150

Carnosol

phyproof^® Reference Substance

• Synonym(s): Picrosalvin
• Empirical Formula (Hill Notation): C₂₀H₂₆O₄
• CAS Number: 5957-80-2
• Molecular Weight: 330.42
• MDL number: MFCD02752467
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: primary reference standard
• product line: phyproof^® Reference Substance
• Assay: ≥95.0% (HPLC)
• manufacturer/tradename: PhytoLab
• application(s): food and beverages
• format: neat
• storage temp.: −20°C
• SMILES string: CC(C)c1cc2[C@@H]3C[C@H]4C(C)(C)CCC[C@]4(C(=O)O3)c2c(O)c1O
• InChI: 1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1
• InChI key: XUSYGBPHQBWGAD-PJSUUKDQSA-N

Description

General description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Application

• Antioxidant and Anti-inflammatory Properties of Carnosol: Research highlights the application of Carnosol in targeting oxidative damage and inflammation through modulation of nuclear factor erythroid2-related factor 2/sirtuin-3 signaling pathways, which are crucial in managing pulmonary diseases and sepsis (Li et al., 2024).


• Carnosol in Cancer Prevention: A detailed study on Carnosol revealed its potential in inhibiting breast cancer progression by regulating STAT3 via ROS-dependent mechanisms, underscoring its role as a valuable bioactive compound in cancer research (Alsamri et al., 2023).


• Neurodegenerative Disease Studies: Ongoing research explores Carnosol′s neuroprotective effects due to its antioxidative properties, presenting it as a promising agent in the study of neurodegenerative diseases, by mitigating oxidative stress and enhancing neuronal survival (Bendaas et al., 2024).

Biochem/physiol Actions

A phenolic diterpene with antioxidant and anticarcinogenic activities.

Other Notes

This compound is commonly found in plants of the genus: salvia

Legal Information

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H317
• Precautionary Statements: P280 - P302 + P352
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable