77043

Mandipropamid

certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

• Synonym(s): 2-(4-Chlorophenyl)-N-[3-methoxy-4-(2-propynyloxy)phenethyl]-2-(2-propynyloxy)acetamide
• Empirical Formula (Hill Notation): C₂₃H₂₂ClNO₄
• CAS Number: 374726-62-2
• Molecular Weight: 411.88
• MDL number: MFCD09751510

Properties

• grade: certified reference material; TraceCERT^®
• Quality Level: 300
• product line: TraceCERT^®
• form: powder
• shelf life: limited shelf life, expiry date on the label
• manufacturer/tradename: Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
• storage temp.: −20°C
• SMILES string: ClC1=CC=C(C(OCC#C)C(NCCC2=CC=C(OCC#C)C(OC)=C2)=O)C=C1
• InChI: 1S/C23H22ClNO4/c1-4-14-28-20-11-6-17(16-21(20)27-3)12-13-25-23(26)22(29-15-5-2)18-7-9-19(24)10-8-18/h1-2,6-11,16,22H,12-15H2,3H3,(H,25,26)
• InChI key: KWLVWJPJKJMCSH-UHFFFAOYSA-N

Description

General description

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ. Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate. Download your certificate at: http://www.sigma-aldrich.com

Mandipropamid is a non-systemic, foliar fungicide belonging to the class of carboxylic acid amides. It is highly active against most foliar oomycete pathogens such as Phytophthora infestans (potato and tomato late blight), Plasmopara viticola (grape downy mildew), and Pseudoperonospara cubensis (cucumber downy mildew). Mandipropamid exerts its fungicidal activity by targeting cellulose synthases, thus inhibiting cell wall biosynthesis in the oomycetes. Being rapidly adsorbed to the wax layer of the plant surface, mandipropamid provides a rainfast and long-lasting barrier to fungal diseases.

According to Regulation (EC) No 1107/2009 mandipropamid is approved for use in European Union (EU). A maximum residue level (MRL) for the presence of mandipropamid (any ratio of constituent isomers) is set according to Regulation (EU) 2020/1565, from 0.01 mg/kg to 30 mg/kg for plant-based products and 0.01 mg/kg to 0.05 mg/kg for products of animal origin. Mandipropamid has to be monitored in the Multiannual Control Programme for Pesticides Residues (MACP), run within the EU and EFTA in/on products of plant origin.

Application

The certified reference material (CRM) is intended to be used as a calibrant for chromatography and other analytical techniques. Mandipropamid CRM may find the following uses: 

• To develop an analytical method for the detection of mandipropamid residues in sesame leaves using high-performance liquid chromatography-ultraviolet detection (HPLC/UVD)
• To examine the effect of fungicide residues - cyazofamid, famoxadone, mandipropamid, and valifenalate on the aroma composition of Vitis vinifera – white grapes of the Godello variety
• To investigate the differences in the bioaccumulation and activity changes of the detoxification enzymes in earthworms (Eisenia fetida) after exposure to R-(-)- and S-(+)-mandipropamid for 42 days in artificial soil
• To investigate the fate and enantioselective behavior of mandipropamid enantiomers in grapes following the field application and, in the wine-making process
• Enantioselective method for the determination of mandipropamid in vegetables (potato and pepper) and fruits (grape and watermelon) by chiral LC coupled with MS/MS

Legal Information

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS09
• Signal Word: Warning
• Hazard Statements: H410
• Precautionary Statements: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable