SRP2112
TFIIB, GST tagged human
recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
Synonym(s):
TF2B, TFIIB
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.26
biological source
human
recombinant
expressed in E. coli
Assay
≥70% (SDS-PAGE)
form
frozen liquid
mol wt
~61.2 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
400 μg/mL
color
clear colorless
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... GTF2B(2959)
Biochem/physiol Actions
The transcription factor IIB (TFIIB) is an essential factor for transcription by RNA polymerase II. TFIIB has been shown to be required for selective binding of RNA polymerase II, TFIIF and TFIID-DNA complex, and for specifying the start site of transcription. Human TFIIB is a single, 35 kDa polypeptide, homologous to yeast factor, the product of the SUA7 gene.
Physical form
Clear and colorless frozen liquid solution
Preparation Note
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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General initiation factors for RNA polymerase II.
R C Conaway et al.
Annual review of biochemistry, 62, 161-190 (1993-01-01)
The general transcription factors of RNA polymerase II.
G Orphanides et al.
Genes & development, 10(21), 2657-2683 (1996-11-01)
S Malik et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(21), 9553-9557 (1991-11-01)
Transcription factor TFIIB is a ubiquitous factor required for transcription initiation by RNA polymerase II. Previous studies have suggested that TFIIB serves as a bridge between the "TATA"-binding factor (TFIID) and RNA polymerase II during preinitiation complex assembly and, more
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