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SML2445

Sigma-Aldrich

PKS21004

≥98% (HPLC)

Synonym(s):

(2S)-N1-[2-[([1,1′-biphenyl]-3-ylcarbonyl)amino]ethyl]-N4-(1,1-dimethylethyl)-2-[(1-oxo-3-phenylpropyl)amino]-butanediamide

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About This Item

Empirical Formula (Hill Notation):
C32H38N4O4
CAS Number:
2095521-90-5
Molecular Weight:
542.67
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(N[C@@H](CC(NC(C)(C)C)=O)C(NCCNC(C1=CC=CC(C2=CC=CC=C2)=C1)=O)=O)CCC3=CC=CC=C3

Biochem/physiol Actions

PKS21004 is highly selective, potent and reversible inhibitor of the Plasmodium falciparum proteasome (Pf20S) β5 subunit. It is not active against mammalian c-20S and i-20S proteasome subunits. PKS21004 is effective against erythrocytic, sexual, and liver-stage parasites. Also it is active against parasites resistant to current antimalarials, and strains from patients in Africa.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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