SAB4700005

Monoclonal Anti-CD95 antibody produced in mouse

clone LT95, purified immunoglobulin, buffered aqueous solution

• Synonym(s): Anti-FAS
• UNSPSC Code: 12352203
• NACRES: NA.41
• conjugate: unconjugated
• application: FACS
• clone: LT95, monoclonal
• species reactivity: human
• citations: 6
• technique(s): flow cytometry: suitable

Properties

• biological source: mouse
• Quality Level: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: LT95, monoclonal
• form: buffered aqueous solution
• species reactivity: human
• concentration: 1 mg/mL
• technique(s): flow cytometry: suitable
• isotype: IgG1
• NCBI accession no.: NM_000043.3
• UniProt accession no.: P25445
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: human ... FAS(355)

Description

General description

CD95, also known as Fas (fatty acid synthase) cell surface death receptor/APO-1, is encoded by the gene mapped to human chromosome 10q23.31. The encoded protein belongs to the tumor necrosis factor receptor superfamily and is expressed on a variety of cells including activated T and B cells. CD95 contains a death domain.

The antibody LT95 reacts with CD95 (Fas/APO-1), a 46 kDa single chain type I glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells. It seems that the antibody LT95 does not induce Fas mediated apoptosis, although it cross-blocks anti-Fas DX2 antibody that recognizes a functional epitope of Fas molecule.

Immunogen

HUT-78 human T cell lymphoma cell line

Application

Monoclonal Anti-CD95 antibody produced in mouse has been used as a apoptosis inducer.

Biochem/physiol Actions

CD95/ Fas (fatty acid synthase) cell surface death receptor interacts with its natural ligand (FasL/CD95 L) and plays a vital role in regulation of T-cell homeostasis, by promoting apoptosis via activation-induced cell death (AICD). Mutation in the gene has been associated with the development of Sézary syndrome (SS) and Canale–Smith syndrome. CD95 gene loss can be used as a genetic marker of PSA recurrence after radical prostatectomy.

Features and Benefits

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Physical form

Solution in Tris buffered saline, pH 8.0, with 15 mM sodium azide.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable