SAB1101510
Anti-SMOX (151-165) antibody produced in rabbit
IgG fraction of antiserum
Synonym(s):
Anti-C20orf16, Anti-PAO, Anti-SMO, Anti-Spermine oxidase
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All Photos(3)
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~56 kDa
species reactivity
human
technique(s)
western blot: 1:500-1:2,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SMOX(54498)
General description
Spermine oxidase (SMOX) gene mapped to human chromosome 20p13, is a flavin adenine dinucleotide (FAD)-dependent oxidase. It encodes nucleus and cytoplasmic specific splice variants.
Immunogen
synthetic peptide corresponding to amino acids 151-165 of human SMOX
Application
Anti-SMOX (151-165) antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
Spermine oxidase (SMOX) catabolizes spermine to spermidine, 3-aminopropanal and hydrogen peroxide. This catalytic activity of SMOX leads to apoptosis and DNA damage in gastric epithelial cells. It is highly expressed in H. pylori infected gastritis tissues and in ulcerative colitis (UC). Induced SMOX expression in breast cancer using spermine analogs is regarded as an effective anticancer treatment regime. It is regarded as a key marker correlating chronic inflammation with epithelial carcinogenesis. Elevation in the SMO levels is observed in inflammatory bowel disease and is implicated in the immunopathogenesis of Citrobacter rodentium infection mediated colitis.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Increased polyamines as protective disease modifiers in congenital muscular dystrophy
Kemaladewi DU, et al.
Human Molecular Genetics, 27(11), 1905-1912 (2018)
D U Kemaladewi et al.
Human molecular genetics, 27(11), 1905-1912 (2018-03-23)
Most Mendelian disorders, including neuromuscular disorders, display extensive clinical heterogeneity that cannot be solely explained by primary genetic mutations. This phenotypic variability is largely attributed to the presence of disease modifiers, which can exacerbate or lessen the severity and progression
Clara Perrone et al.
Frontiers in cell and developmental biology, 11, 1061570-1061570 (2023-02-10)
Rhabdomyosarcoma (RMS) is a pediatric myogenic soft tissue sarcoma that includes fusion-positive (FP) and fusion-negative (FN) molecular subtypes. FP-RMS expresses PAX3-FOXO1 fusion protein and often shows dismal prognosis. FN-RMS shows cytogenetic abnormalities and frequently harbors RAS pathway mutations. Despite the
Freddy López-Contreras et al.
Frontiers in pharmacology, 10, 1670-1670 (2020-04-08)
Non-small cell lung cancer (NSCLC) is the most lethal and prevalent type of lung cancer. In almost all types of cancer, the levels of polyamines (putrescine, spermidine, and spermine) are increased, playing a pivotal role in tumor proliferation. Indomethacin, a
Armand W J W Tepper et al.
PloS one, 17(4), e0267046-e0267046 (2022-04-23)
The enzyme spermine oxidase (SMOX) is involved in polyamine catabolism and converts spermine to spermidine. The enzymatic reaction generates reactive hydrogen peroxide and aldehydes as by-products that can damage DNA and other biomolecules. Increased expression of SMOX is frequently found
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