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M9917

Sigma-Aldrich

Mannan−Agarose

saline suspension

Synonym(s):

Mannan Binding Protein Agarose

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About This Item

MDL number:
MFCD00213010
UNSPSC Code:
23151817
NACRES:
NA.56

biological source

plant

Quality Level

200

form

saline suspension

technique(s)

affinity chromatography: suitable

matrix

cross-linked 4% beaded agarose

matrix activation

cyanogen bromide

matrix attachment

hydroxyl

matrix spacer

1 atom

capacity

≥30 mg/mL binding capacity (concanavalin A)

suitability

suitable for chromatography

storage temp.

2-8°C

Application

Mannan-agarose is used in protein chromatography, affinity chromatography and carbohydrate matrices. Mannan-agarose has been used in studies assessing poly(ADP-ribosyl)ation of mannose-binding lectin out of human kidney cells and to inform mannose-associated serine protease (MASP) activated components of the coagulation system. Mannan-agarose has also been used to study the innate immunity and resistance to Aeromonas salmonicida exhibited by the sea lamprey (Petromyzon marinus), a parasitic cartilaginous fish of the North American Great Lakes and a predator of many bony fish species of commercial importance to the fishing industry. Mannan-Agarose has been used to deplete rabbit anti-mannose-binding lectin (MBL) polyclonal antiserum of anti-mannan antibodies.

Physical form

Suspension in 1.0 M NaCl, 10 mM imidazole containing preservative

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

CAS No.

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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R J Raemaekers et al.
European journal of biochemistry, 265(1), 394-403 (1999-09-22)
Phytohemagglutinin (Phaseolus vulgaris agglutinin; PHA; E- and L-forms) and snowdrop lectin (Galanthus nivalis agglutinin; GNA) were expressed in Pichia pastoris using native signal peptides, or the Saccharomyces alpha-factor preprosequence, to direct proteins into the secretory pathway. PHA and GNA were
Identification of Mannose-Binding Protein from Milkfish
(Chanos chanos F.) Serum
Argayosa AM, et al.
Biological Chemistry, 277- 288 (2015)
Jean-Philippe Gourdine et al.
Fish & shellfish immunology, 22(5), 498-509 (2006-12-16)
This work relates to the characterisation of the predominant gill protein of the white clam, Codakia orbicularis (Linné, 1758), which harbours endosymbiotic sulphur-oxidising chemoautotrophic bacteria. Total RNA was extracted from the clam to perform 3'rapid amplification of cDNA ends (3'RACE)
T Kawai et al.
Glycobiology, 8(3), 237-244 (1998-05-16)
Mannan-binding protein (MBP) is a member of the collectin family of protein. There are two types of MBP, MBP-A and MBP-C, which were found in rodent (rats and mice), rhesus monkey, and cynomolgus monkey, while chimpanzee and human have only
Kazuhiko Takahara et al.
International immunology, 16(6), 819-829 (2004-04-21)
The mouse (m) DC-SIGN family consists of several homologous type II transmembrane proteins located in close proximity on chromosome 8 and having a single carboxyl terminal carbohydrate recognition domain. We first used transfected non-macrophage cell lines to compare the polysaccharide
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