I1877

Isocitric Dehydrogenase (NADP) from porcine heart

Type I, 0.5-3.0 unit/mg solid (plus numerous enzyme activities associated with porcine heart)

• Synonym(s): threo-D_s-Isocitrate: NADP⁺ oxidoreductase, ICDH, IDH
• CAS Number: 9028-48-2
• Enzyme Commission number: 1.1.1.42 (BRENDA, IUBMB)
• EC Number: 232-835-3
• MDL number: MFCD00131420
• UNSPSC Code: 12352204
• NACRES: NA.54

Properties

• biological source: Porcine heart
• type: Type I
• form: solid
• specific activity: 0.5-3.0 unit/mg solid (plus numerous enzyme activities associated with porcine heart)
• storage temp.: −20°C

Description

Biochem/physiol Actions

Isocitrate dehydrogenase (IDH) plays a major role in the Krebs cycle by catalyzing the oxidative decarboxylation of isocitrate. The oxidative decarboxylation of isocitrate generates α-ketoglutarate and NADPH. NADPH produced is essential for the production of fatty acids and cholesterol. This NADP-dependent molecules serves as homodimers.

Quality

Crude

Unit Definition

One unit will convert 1.0 μmole of isocitrate to α-ketoglutarate per min at pH 7.4 at 37°C.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H334
• Precautionary Statements: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves