I0654

Interleukin-1 Soluble Receptor, Type I human

>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

• Synonym(s): (IL-1 sRI)
• MDL number: MFCD01323730
• UNSPSC Code: 51111800
• NACRES: NA.32

Properties

• biological source: human
• Quality Level: 100
• recombinant: expressed in NSO cells
• Assay: >97% (SDS-PAGE)
• form: lyophilized powder
• mol wt: 36 kDa
• packaging: pkg of 0.1 mg
• impurities: endotoxin, tested
• UniProt accession no.: P14778
• storage temp.: −20°C
• Gene Information: human ... IL1R1(3554)

Description

General description

Interleukin-1 type 1 receptor (IL1R1) is a glycoprotein. It is mainly expressed on endothelial cells, epithelial cells, hepatocytes, fibroblasts, epidermal dendritic cells as well as T lymphocytes.

Biochem/physiol Actions

Interleukin-1 (IL-1), a cytokine, is a key regulator of acute and chronic inflammation. The IL-1 associated responses are achieved by association of IL-1 with IL-1 type 1 receptor (IL1R1).

Recombinant human IL-1 soluble receptor I is a transmembrane protein and a member of the immunoglobulin superfamily. It is expressed predominantly by T cells, fibroblasts, and endothelial cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5.0 mg bovine serum albumin

Analysis Note

The bioactivity is measured by its ability to inhibit the IL-1β-dependent proliferation of a murine helper T cell line, D10.G4.1.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable